响应面法优化柿叶总黄酮缓释微丸的载药量  

Optimization of Drug Loading Rate of Persimmon Leaf Total Flavonoids Sustained Release Pellets Using Response Surface Methodology

作　　者：王兰[1] 顾欣[1] 赵麟[1] 龚频[1] 

机构地区：[1]陕西科技大学生命科学与工程学院,西安710021

出　　处：《天然产物研究与开发》2014年第8期1182-1187,共6页Natural Product Research and Development

基　　金：陕西省教育厅2013年科学研究计划;自然科学专项资助项目(2013JK0767)

摘　　要：本文研究了响应面法优化柿叶总黄酮缓释微丸的载药量。以单因素试验为基础,以海藻酸钠浓度、壳聚糖浓度、投药量和反应温度为因素,缓释微丸的载药量为响应值,采用响应面试验设计,依次对各因素的显著性及其交互作用进行分析,最终优化了柿叶总黄酮缓释微丸的载药量。当海藻酸钠浓度为2.75%、壳聚糖浓度为2.08%、投药量为35.94%、反应温度为51℃时载药量为22.41%。响应面分析法优化柿叶总黄酮缓释微丸的载药量是可行的。Response surface methodology was applied to optimize the drug loading rate of persimmon leaf total flavonoids sustained release pellets. On the basis of single factor experlment,the concentration of sodium alginate, the concentration of chitosan, quantity of reagent and reaction temperature were treated as independent variable and drug loading rate was used as a response value. The significance of each factor and their interactions were investigated by response surface methodology. Finally,the optimized preparation technology was ascertained as ： the concentration of sodium alginate was 2.75% ,the concentration of chitosan was 2.08% ,quantity of reagent was 35.94% ,reaction temperature was 51℃ ,and drug loading rate was 22.41%. Using response surface methodology to optimize the preparation technology of sustained release pellets from persimmon leaf total flavonoids was feasible.

关 键 词：柿叶总黄酮 缓释微丸 响应面法 载药量 

分 类 号：R91[医药卫生—药学]