蚊虫两种靶标抗性机制的研究进展  

PROGRESS IN TWO KINDS OF TARGET RESISTANCE MECHANISMS IN MOSQUITO

作　　者：赵明惠[1,2] 李春晓[2] 赵彤言[1,2] 

机构地区：[1]安徽医科大学,合肥230032 [2]军事医学科学院微生物流行病研究所,病原微生物生物安全国家重点实验室,北京100071

出　　处：《寄生虫与医学昆虫学报》2014年第2期138-146,共9页Acta Parasitologica et Medica Entomologica Sinica

基　　金：国家科技重大传染病专项课题（2012ZX10004-219）

摘　　要：对蚊虫抗性机制的研究在其抗性监测和环境治理方面具有重要的意义。人们经过多年的研究发现，蚊虫对杀虫剂的抗性与其行为、生理功能的改变、解毒功能的增强以及靶标位点的不敏感性均有关系。随着分子生物学的发展，基因芯片技术的普及和后基因组时代的到来，人们对蚊虫抗性形成和进化的研究已经从分子水平全面展开，已经发现并克隆出了一些与抗药性相关的靶标基因。本文将对与蚊虫抗性相关的钠离子通道和乙酰胆碱酯酶基因的研究现状作一综合介绍。Researching on molecular mechanisms of mosquito resistance is very important to develop effective strategies for resistance monitoring and environmental management. After years of studies, researchers have found that mosquito resistance to insecticides was connected with the change of their behaviors and physiological functions, the enhancement of detoxification function and the reducing sensibility of target sites. With the development of molecular biology, gent chip technology and the popularity of the post-genomic era, researches on the formation and evolution of insect resistance have reached to the molecular level. A number of target genes associated with resistance have been discovered and cloned. This paper will make a comprehensive introduction for two target resistance mechanisms, the sodium channel and acetylcholinesterase gene, associated with mosquito resistance.

关 键 词：蚊虫 靶标抗性 钠离子通道 乙酰胆碱酯酶 

分 类 号：Q969.442.1[生物学—昆虫学]