心血管疾病新的标志物:抗apoA-1 IgG  

New Markers for Cardiovascular Disease:the Anti-apoA-1 IgG

作　　者：邱波 佘强[1] 

机构地区：[1]重庆医科大学附属第二医院心内科

出　　处：《医学综述》2014年第15期2689-2691,共3页Medical Recapitulate

基　　金：国家自然科学基金(NSFC:81270211;81100088);高等学校博士学科点专项科研基金(20125503110009);重庆教委科学技术研究项目(KJ130324)

摘　　要：心血管疾病发生、发展的基本特征是动脉粥样硬化和动脉粥样硬化血栓形成。大量的证据表明,体液免疫在心血管疾病中可能发挥着重要的作用。最近的研究表明,载脂蛋白A1自身抗体(抗apoA-1 IgG)的升高与心血管疾病的高风险有关,如急性冠状动脉综合征、严重颈动脉狭窄、终末期肾病、肥胖、风湿性关节炎、系统性红斑狼疮等。该文就apoA-1 IgG在预测和诊断心血管疾病中的能力及其在调节动脉粥样硬化中的作用予以综述。The basic characteristics of cardiovascular disease development is atherosclerosis and atherosclerosis thrombosis. A lot of evidence indicate that humoral immunity may play an important role in cardiovascular disease. Recent studies show that apolipoprotein A1 autoantibodies（ anti-apoA-1 IgG） increase is related with a high risk of cardiovascular disease, such as acute coronary syndrome, severe carotid stenosis, end stage renal diseas, obesity, rheumatoid arthritis, systemic lupus erythematosus and so on. Here is to make a review of the capabilities of anti-apoA-1 IgG in the prediction and diagnosis of cardiovascular disease, as well as its role in regulating atheroselerosis.

关 键 词：心血管疾病 动脉粥样硬化 自身抗体 载脂蛋白A1自身抗体 

分 类 号：R714.252[医药卫生—妇产科学]