松弛素抗纤维化作用的研究进展  

The Research Progress of Anti-Fibrosis Role of Relaxin

作　　者：朱艳艳[1] 张怀勤[1] 周浩[1] 

机构地区：[1]温州医学院附属第一医院心内科,浙江温州325000

出　　处：《医学综述》2014年第15期2714-2716,共3页Medical Recapitulate

摘　　要：肽类激素松弛素是一个相对分子质量为6×103的小分子多肽。松弛素有潜在的抗纤维化作用,其不仅抑制胶原合成、沉积,成纤维细胞活化、增殖、分化以及上皮/内皮细胞间质转化,还可增强胶原纤维降解,且在各种心脏疾病和肾脏疾病模型实验中得到了充分的证明。该文就松弛素抗心脏纤维化和肾脏纤维化的作用机制予以综述。The peptide hormone relaxin is a small polypeptide with a relative molecular mass of only 6 ×10^3. Relaxin has potential effect on anti-fibrosis through inhibiting extracellular matrix synthesis and deposit, fibroblast cell differentiation and epithelium-mesenchymal transformation and promoting collagen degrada- tion, which has been proved in many experimental models of heart diseases and kidney diseases. Here is to make a review of the research advances in the function mechanisms of relaxin in anti-fibrosis in the heart and kidney.

关 键 词：松弛素 纤维化 内皮间质转化 细胞外基质 

分 类 号：R544.1[医药卫生—心血管疾病] Q78[医药卫生—内科学]