心力衰竭患者体质量指数对脑钠肽影响的研究进展  

Research Progress on the Influence of Cardiac Heart Failure Patients' Body Mass Index on Their BNP Levels

作　　者：张燕波[1] 薛博文[1] 姜东炬[1] 

机构地区：[1]大连解放军第210医院心内科,辽宁大连116021

出　　处：《医学综述》2014年第15期2717-2719,共3页Medical Recapitulate

摘　　要：以往的研究显示,同等严重程度的心力衰竭患者,肥胖患者脑钠肽(BNP)水平相对较低。研究发现BNP和体质量指数(BMI)呈负相关。肥胖患者较低水平的BNP的机制尚不清楚,可能是多因素共同作用的结果。BMI影响BNP在心力衰竭诊断切点的选择,在严重病态肥胖患者(BMI≥35 kg/m2)中,为保持90%的诊断灵敏度,必须采用一个较低的BNP诊断切点。相反,在偏瘦患者(BMI<25 kg/m2)中,为增加诊断的特异性,可以采用一个较高的BNP诊断切点。Prior studies have shown that brain natriurctic peptide （BNP） levels tend to run lower in obese patients of cardiac heart failure（CHF） rather than other patients with the same severity. It has been found that the level of BNP is negatively related to the body mass index（BMI）. The mechanism responsible for the lower BNP levels in obese patients has not been fully elucidated and is likely muhifaetorial. BMI influences the selection of the cut-points for BNP in diagnosing acute CHF. For severe and morbid obese patients （ BMI 1〉 35 kg/m2 ）, a lower cut-point should be used to preserve 90% sensitivity. Conversely, a higher cut- point may be used in lean patients （ BMI 〈 25 kg/m2 ） to increase specificity.

关 键 词：脑钠肽 体质量指数 诊断切点 

分 类 号：R541.61[医药卫生—心血管疾病]