环孢素A治疗儿童紫癜性肾炎的研究进展  

Research Progress of Cyclosporin A Treatment for Henoch-Schonlein Purpura Nephritis in Children

作　　者：刘华杰[1] 黄文彦[1] 

机构地区：[1]上海交通大学附属儿童医院肾脏风湿科,上海200040

出　　处：《医学综述》2014年第15期2774-2776,共3页Medical Recapitulate

摘　　要：过敏性紫癜(HSP)是儿童时期最常见的一种血管炎症性疾病,主要表现为皮肤紫癜、并常累及关节、胃肠道和肾脏。其中,肾脏损害是影响HSP预后的最严重的并发症之一。迄今为止,尽管免疫抑制剂已广泛用于治疗过敏性紫癜性肾炎(HSPN),但对于免疫抑制剂的选择尚存在争议。近年来,有关环孢素A治疗紫癜性肾炎已有报道,但尚缺乏大规模的随机对照研究。该文就环孢素A治疗HSPN的研究进展予以综述。Henoch-schonlein purpura（HSP） is the most common vasculitis in children,characterized by non-thmmbocytopenic purpura, arthritis/arthralgia, abdominal pain, and glomerulonephritis. Renal involvement is one of the most serious long-term complications of HSP. Up to now, although multiple immunosuppressive drugs have been used to treat severe henoch-schonelin purpura nephritis （ HSPN）, there is a huge debate over the selectivity of various agents. Recently, a few studies have suggested that cyclosporin A （CsA） might have a beneficial effect in children with severe HSPN, but the numbers of patients included are limited. Here is to make a brief review of CsA treatment for HSPN.

关 键 词：过敏性紫癜 免疫抑制剂 环孢素A 儿童 

分 类 号：R453.9[医药卫生—治疗学]