基于UFLC-Q-TOF-MS/MS技术的盐酸克林霉素棕榈酸酯分散片杂质的研究  

Analysis of Impurities in Clindamycin Palmitate Hydrochloride Dispersible Tablets Through UFLC-Q-TOF-MS/MS

作　　者：黄昕[1] 张超 周翠兰 邹威[1] 苏薇薇[1] 彭维[1] 

机构地区：[1]中山大学生命科学学院,广东广州510275 [2]广州一品红制药有限公司,广东广州510760

出　　处：《中山大学学报（自然科学版）》2014年第4期101-106,共6页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：广东省科技计划资助项目(2012B090600020)

摘　　要：采用UFLC-Q-TOF-MS/MS技术,在正离子模式下,根据各物质的质谱裂解规律,研究鉴定出盐酸克林霉素棕榈酸酯分散片中16种杂质,其中克林霉素九酸酯、克林霉素十酸酯、克林霉素十一酸酯、克林霉素十三酸酯为首次检到,本研究为其质量监控提供了实验依据。Sixteen impurities in clindamycin palmitate hydrochloride dispersible tablets were identified according to their fragmentation patterns and characteristic fragment ions by UFLC-Q-TOF-MS/MS in a positive mode .Among them , clindamycin nonanoate , clindamycin decanoate , clindamycin monodecano-ate, clindamycin tridecanoate were firstly detected .These results provided a basis for quality control of clindamycin palmitate hydrochloride dispersible tablets .

关 键 词：盐酸克林霉素棕榈酸酯分散片 杂质 液质联用分析 

分 类 号：TQ460.7[化学工程—制药化工]