冠心病患者血清胱抑素C、一氧化氮、超氧化物歧化酶及超敏C反应蛋白水平变化及与冠脉狭窄程度的相关性  

Level Changes of CysC,NO,SOD and hs-CRP in Serum and the Relationship of Coronary Artery Lesion in Coronary Heart Disease

作　　者：沈云峰[1] 胡远贵[1] 张洪波[1] 田强[1] 

机构地区：[1]武汉市第六医院检验科,武汉430015

出　　处：《微循环学杂志》2014年第3期28-31,共4页Chinese Journal of Microcirculation

基　　金：武汉市卫生局临床医学科研项目(WX11B14)

摘　　要：目的:分析血清胱抑素C(CysC)、一氧化氮(NO)、超氧化物歧化酶(SOD)及超敏C反应蛋白(hs-CRP)水平与冠状动脉狭窄程度的关系及其临床意义。方法:162例心血管病患者依据冠脉造影结果分为对照组(冠脉狭窄<50%,n=40);单支病变组(一支冠脉狭窄≥50%,n=44);双支病变组(两支冠脉狭窄≥50%,n=43);多支病变组(两支以上冠脉狭窄≥50%,n=35)。对四组患者进行冠脉狭窄Gensini积分及血清CysC、NO、SOD及hs-CRP水平检测,分析冠心病患者各指标变化及其与Gensini积分的相关性。结果:单支病变组、双支病变组、多支病变组的CysC和hs-CRP水平均高于对照组(P<0.05),并依次递增;单支病变组、双支病变组、多支病变组的NO及SOD水平均低于对照组(P<0.05),并依次递减。冠心病患者Gensini积分与血清CysC和hs-CRP水平呈正相关,相关系数分别为0.473,0.429(P<0.05);与NO和SOD水平呈负相关,相关系数分别为-0.356,-0.384(P<0.05)。结论:冠心病患者冠脉狭窄程度的增加与CysC、hs-CRP水平升高及NO、SOD水平降低有明显相关性。Objective：To analyze correlation and clinical value the contents of cystatin C（CysC）,nitric oxide（NO）,super oxide dismutase（SOD）and high-sensitivity C-reactive protein（hs-CRP）in serum and coronary lesion in patients with coronary heart disease（CHD）.Method：According to the severity of coronary artery lesion,162 cases were divided into four groups：normal compared group（40 cases）;simple branch pathological group（44 cases）;double branch pathological group（43 cases）;multi-branch pathological group（35 cases）.All cases were tested CysC,NO,SOD and hs-CRP in serum.To analyze the correlation between their level changes of CysC,NO,SOD,hs-CRP and coronary lesion Gensini.Results：The level of CysC and hs-CRP in simple branch pathological group,double branch pathologi-cal group,multi-branch pathological group were higher than normal compared group（P〈0.05）,increased gradually from simple branch pathological group to multi-branch group.The level of NO and SOD in simple branch pathologi-cal group,double branch pathological group,multi-branch pathological group were lower than normal compared group（P〈0.05）decreased gradually from simple branch pathological group to multi-branch group.The level of Cy-sC and hs-CRP had respectively significant positive relationship to coronary lesion Gensini in the CHD patients（r=0.473,0.429）,the level of NO or SOD had respectively significant negative relationship to coronary lesion Gensini in the CHD patients （r=-0.356,-0.384）（P〈0.05）.Conclusion：There were significant relationships between aggravation of coronary artery lesion and the level of CysC,hs-CRP increasing,the level of NO,SOD reducing.

关 键 词：胱抑素C 一氧化氮 超氧化物歧化酶 超敏C反应蛋白 冠状动脉病变 

分 类 号：R541.4[医药卫生—心血管疾病]