共载药微包纳胶囊的释放性能研究  

Research on Co-loading Drug Release Properties in Nanoparticles Embedded Microcapsules

作　　者：汤晓琳[1] 刘源岗[1,2] 王士斌[1,2] 孙学战[1] 

机构地区：[1]华侨大学化工学院,厦门361021 [2]华侨大学生物材料与组织工程研究所,厦门361021

出　　处：《材料导报》2014年第16期63-66,76,共5页Materials Reports

基　　金：国家自然科学基金(31000441);福建省自然科学基金(2013J01189)

摘　　要：以微包纳胶囊共载两种药物,考察它们之间的联合释放性能。结果显示,共载卡培他滨(Capecitabine,CAP)和贝伐单抗/木瓜蛋白酶时,微包纳胶囊的多腔室结构显示出了延缓CAP释放的效果,大分子的累积释放速率更快;在释放的中后期,微包纳胶囊对两种药物有很好的顺序释放效果。而共载CAP和甲氨蝶呤时,微包纳胶囊的多腔室结构对药物的释放抑制有限,两种药物的释放趋势基本一致。A total of two drugs were embedded in nanoparticles embedded microcapsules （NEMs）, and the joint release properities between them were investigated. Results showed that when co-loaded eapeeitabine （CAP） and bevaeizumab/papain, multi-chamber structure of NEMs exhibited the effect of delaying the release of CAP and the cumulative release rate of macromolecules was higher. What was more, these two drugs had very good orderly release results in NEMs in the middle and latter processes. However, coqoading CAP and methotrexate, multi-chamber structure of NEMs had limited suppression of drug release and basic trend of the two drugs was consistent.

关 键 词：微包纳胶囊 共载 释放 

分 类 号：R979.1[医药卫生—药品]