PLA嵌段PEG聚合物胶束载药系统的研究进展  

Progress of PLA Block PEG Copolymers Micelles Used in Drug Delivery System

作　　者：涂增清 李敬豪 周月广 

机构地区：[1]丽珠医药集团股份有限公司丽珠医药研究所,广东珠海519020

出　　处：《广州化工》2014年第15期13-16,33,共5页GuangZhou Chemical Industry

摘　　要：介绍了PLA嵌段PEG聚合物的合成、性质和质量评价方法,对其所形成的载药胶束的性能评价指标进行了总结,并综述了其作为胶束在药物载药系统中的应用,尤其是应用在抗肿瘤药物上的研究进展。结论:PLA嵌段PEG聚合物有良好的生物可降解性和相容性,为目前胶束载药系统中聚合物的研究热点,具有广泛应用前景。Synthesis, properties as well as property assessment method of PLA block PEG copolymers were introduced , then the performance evaluations of the micelles formed by these copolymers were briefly reviewed , finally their applications for micelles in drug delivery system were summarized , especially in the field of anticancer drugs.PLA block PEG copolymers possessed good biodegradability and biocompatibility and were the current research focuses of micelles delivery system , which had widely application prospects.

关 键 词：聚乳酸-聚乙二醇 嵌段聚合物 生物可降解性 药物载药系统 

分 类 号：R943[医药卫生—药剂学]