普鲁卡因混合液防治食管癌放射性食管炎的效果观察  

Efficacy observation of mixture of procaine for radiation esophagitis of esophageal cancer

作　　者：江妙玲[1] 吴碧娟[1] 林婷[1] 

机构地区：[1]汕头大学医学院附属肿瘤医院放二科,广东汕头515031

出　　处：《西部医学》2014年第8期1054-1055,1058,共3页Medical Journal of West China

摘　　要：目的观察普鲁卡因混合液防治食管癌放射性食管炎的临床效果。方法将70例食管癌患者随机分为治疗组和对照组各35例,两组均采用常规口腔护理方法,治疗组自放疗1周后开始,于饭前含服普鲁卡因混合液,对照组于饭后及睡前予温生理盐水含服。并在放疗剂量20Gy、40Gy、60Gy对两组患者的放射性食管炎发生情况进行对比分析。结果治疗组与对照组放射性食管炎发生情况在放疗剂量20Gy,差异无统计学意义(P>0.05),当放疗剂量达40Gy时,治疗组食管炎以1级为主,占65.7%,而对照组以2,3级为主,占82.7%,两组比较,差异有统计学意义(P<0.05)。当放疗剂量达60Gy时,治疗组食管炎以1,2级为主,占82.7%,而对照组以3级为主,占62.9%。两组比较,差异有统计学意义(P<0.01)。结论普鲁卡因混合液对食管癌患者放射性食管炎有减轻作用。Objective To observe efficacy of mixture of procaine for radiation esophagitis of esophageal cancer.Methods 70 cases of esophageal cancer patients were randomly divided into the treatment group and the comparison group.Besides the conventional oral care,the patients in the treatment group were received mixture of procaine before eating,and the patients in the comparison group swallowed the warm saline after meal and before sleep.The radiation esophagitis between the two groups were compared at dose of 20 Gy,40 Gy and 60 Gy.Results The radiation esophagitis had no significant difference between the two groups at dose of 20 Gy （P〉0.05）.The main radiation esophagitis of the treatment group was grade 1 （65.7%） at dose of 40 Gy,while the comparison group were grade 2 and 3 （82.7%）,significantly different from the treatment group （P〈0.05）.At dose of 60 Gy,the main radiation esophagitis of the treatment group were grade 1 and 2 （82.7%）,but in the comparison group it was grade 3 （62.9%）,significantly different from the treatment group （P〈0.01）.Conclusion Mixture of procaine can reduce the radiation esophagitis of esophageal cancer.

关 键 词：普鲁卡因混合液 食管癌 放射性食管炎 

分 类 号：R818.05[医药卫生—放射医学]