H 型高血压与颈动脉斑块发生及性质的相关性分析  

Correlation between type H hypertension and incidence and characteristics of carotid arteriosclerosis plaques

作　　者：傅昱[1,2] 赵新斌[1] 刘雅娟[3] 张惠英[1] 米国青 王连辉[4] 马建英[4] 

机构地区：[1]河北联合大学附属医院CT室,河北唐山063000 [2]唐山市第九医院CT室 [3]唐山市第九医院超声室 [4]唐山市第九医院神经内科

出　　处：《实用放射学杂志》2014年第7期1103-1106,共4页Journal of Practical Radiology

摘　　要：目的：分析 H 型高血压与颈动脉斑块发生及性质的相关性。方法运用256层螺旋 CT 对198例原发性高血压患者行颈动脉血管造影检查。依据血浆同型半胱氨酸（homocysteine,Hcy）水平将其分为 H 型及非 H 型高血压2组,比较2组患者颈动脉斑块发生及性质的差异。再按照血压水平分层,分别比较2组上述的差异。结果颈动脉总斑块在2组间的构成（OR =1.931,95% CI 1.035-3.601,χ2=4.281,P=0.039）及颈动脉不稳定斑块在2组间的构成（OR=2.780,95% CI 1.631-4.738,χ2=14.123,P=0.000）差异有统计学意义,而颈动脉稳定斑块在2组间的构成（OR=1.622,χ2=2.731,P =0.098）差异无统计学意义；按血压水平分层,颈动脉总斑块在2组间的构成（ORMH =2.137,95% CI 1.723-2.651,χ2=47.767,P =0.000）及颈动脉不稳定斑块在2组间的构成（ORMH =2.971,95% CI 1.649-5.354,χ2=13.135,P =0.000）差异仍有统计学意义。结论颈动脉斑块的发生及斑块的不稳定性均与 H 型高血压有关,且不受血压水平的影响。Objective To study the correlation between type H hypertension and incidence and characteristics of carotid arterio-sclerosis plaques.Methods 1 98 patients with primary hypertension underwent 256-slice spiral CT carotid angiography.According to the level of homocysteine,the subjects were divided into two groups with type H and non-type H hypertension.The incidence and characteristics of the carotid arteriosclerosis plaques were compared between two groups.Then the patients were divided into three grades according to blood pressure levels,and the difference in the grades between two groups was compared.Results Statistically significant difference was showed in composition of the total plaques between two groups （OR=1.931,95% CI 1.035-3.601,χ2 =4.281,P =0.039）,so was the composition of unstable plaques （OR=2.780,95% CI 1.631-4.738,χ2 =14.123,P =0.000）.No significant difference was found in the composition of stable plaques between two groups （OR=1.622,χ2 =2.731,P =0.098）.The grads of blood pressure levels also showed a statistically significant difference in the composition of total plaques between the two groups （ORMH =2.137,95% CI 1.723-2.65 1,χ2 =47.767,P =0.000）,so was the composition of unstable plaques （ORMH =2.971, 95% CI 1.649 - 5.354,χ2 = 13.135,P = 0.000 ）.Conclusion The incidence and characteristics of the carotid arteriosclerosis plaques are associated with type H hypertension,and they are not influenced by the blood pressure levels.

关 键 词：高血压 动脉粥样硬化 血管造影术 计算机体层成像 

分 类 号：R544.1[医药卫生—心血管疾病] R543.5[医药卫生—内科学]