双指数模型 DWI在乳腺良恶性病变鉴别诊断中的价值  

The value of DWI based on biexponential model in differential diagnosis of benign and malignant breast lesions

作　　者：何杰[1] 张焱[1] 程敬亮[1] 胡瑛[1] 王岸飞[1] 

机构地区：[1]郑州大学第一附属医院磁共振科,河南郑州450052

出　　处：《实用放射学杂志》2014年第7期1137-1140,共4页Journal of Practical Radiology

摘　　要：目的：探讨多 b 值双指数信号衰减模型的扩散加权成像（DWI）对乳腺良恶性病变的鉴别诊断价值。方法对57例临床乳腺触诊或乳腺 X 线摄影、B 超检查发现肿块的患者行多 b 值双指数信号衰减模型的 DWI 检查（12个 b 值,分别为0、10、20、50、100、200、400、600、800、1000、1200、1500 s/mm2）,其中良性肿块19例（24处病灶,良性组）,恶性肿块38例（47处病灶,恶性组）。通过 Advantage Windows 4.5工作站测量病灶的慢速表观扩散系数（ADCslow ）值、快速表观扩散系数（ADCfast ）值及快速扩散成分所占比例（ffast ）,比较良性组和恶性组之间这些参数是否有统计学差异。结果良性组 ADCslow、ADCfast 及 ffast 值分别为（1.434±0.291）×10-3 mm2/s、（2.744±0.050）×10-3 mm2/s 及（0.677±0.130）%,恶性组 ADCslow、ADCfast 及 ffast 值分别为（0.614±0.196）×10-3 mm2/s、（2.692±0.068）×10-3 mm2/s 及（0.446±0.112）%。2组之间 ADCslow 和 ffast 值差异均有统计学意义,ADCfast 值差异无统计学意义。结论多 b值双指数信号衰减模型的 DWI 可为鉴别诊断乳腺良恶性病变提供有价值的组织学参数（ADCslow 值及 ffast 值）。Objective To investigate the application value of DWI based on biexponential signal decay model with extended b-fac-tor range in differential diagnosis of benign and malignant breast lesions.Methods A total of 57 patients with breast tumor under-went DWI based on the biexponential model with 12 b-factors （0,10,20,50,100,200,400,600,800,1000,1 200 and 1 500 s/mm2 ）, including benign lesions in 1 9 patients （24 breast tumors,defined as benign group）and malignant ones in 38 （47 tumors,defined as malignant group ）.The values of slow apparent diffusion coefficient,fast apparent diffusion coefficient and fraction of fast ADC of le-sions were measured at a workstation （Advantage Windows 4.5）.Differences in these parameters between the benign and malignant groups were compared.Results The ADCslow,ADCfast and ffast were（1.434±0.291）×10 -3 mm2/s,（2.744±0.050）×10 -3 mm2/s and （0.677±0.130）% in benign group,and （0.614±0.196）×10 -3 mm2/s,（2.692±0.068）×10 -3 mm2/s and （0.446±0.112）% in malig-nant one,respectively.The statistical differences in ADCslow and ffast were found between two groups （P 〈0.05）,whereas no difference in ADCfast was found.Conclusion Biexponential signal decay model of DWI with extended b-factor range can provide helpful tissue characterization parameters for the differential diagnosis of benign and malignant breast lesions.

关 键 词：扩散加权成像 乳腺磁共振成像 双指数信号衰减 

分 类 号：R445.2[医药卫生—影像医学与核医学] R655.8[医药卫生—诊断学]