阿折地平和氨氯地平对轻中度原发性高血压老年患者血压和血压变异性的影响  

Clinical effects of azelnidipine and amlodipine on blood pressure and blood pressure variability in elderly patients with mild to moderate essential hypertension

作　　者：石爱平[1] 王晓洪[2] 朱春健[2] 

机构地区：[1]泰兴市人民医院,江苏泰兴225400 [2]泰州市中医院,江苏泰州225300

出　　处：《中国新药与临床杂志》2014年第7期542-545,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的对比研究阿折地平和氨氯地平对轻中度原发性高血压老年患者血压和血压变异性(BPV)的影响。方法选取轻中度原发性高血压老年患者60例,分为对照组和试验组,分别口服氨氯地平5 mg·d-1或阿折地平8 mg·d-1,治疗12周,监测患者血压,分别于治疗前后测量24 h动态血压,比较两组患者的血压、BPV和平滑指数(SI)。结果治疗12周后,对照组患者收缩压(SBP)和舒张压(DBP)分别为(133.6±10.6)mmHg和(89.9±8.2)mmHg,试验组为(124.7±10.8)mmHg和(85.3±9.3)mmHg,均较治疗前显著下降(P<0.01),两组相比有显著差异(P<0.05)。经动态血压监测,两组各时段SBP和DBP及相应时段的BPV均较治疗前明显下降(P<0.01),试验组24hSBP、日间SBP、清晨SBP下降幅度更为显著(P<0.05);两组各时段BPV及SI均无显著差异(P>0.05)。结论阿折地平显著降低老年原发性高血压患者血压,且血压波动较小,降压效果优于氨氯地平。AIM To compare the effects of azelnidipine and amlodipine on blood pressure and blood pressure variability （BPV） in elderly patients with mild to moderate essential hypertension. METHODS Sixty elderly patients with mild to moderate essential hypertension were divided into control group and trial group. The patients were given amlodipine （5 mg·d-1） and azelnidipine （8 mg·d-1） for 12 weeks, respectively. The blood pressures of the patients were tested. Before and after the treatment, 24 h ambulatory blood pressure monitoring was conducted. The effects on blood pressure, BPV and 24 h systolic blood pressure （SBP） /24 h diastolic blood pressure （DBP） smooth index （SI） were compared between the two groups. RESULTS After 12 weeks treatment, SBP and DBP were significantly declined in the control group （（133.6 ± 10.6） mmHg and （89.9 ±8.2） mmHg respectively） and the trial group （（124.7±10.8） mmHg and （85.3±9.3） mmHg）. And the antihypertensive effect of the trail group was greater than that of the control group （P 〈 0.05）. All indices of blood pressure and BPV were improved obviously in both groups （P 〈 0.01 ）. 24hSBP, dSBP and mSBP were declined significantly in the trail group than the control group （P 〈 0.05）. There were no significant difference of BPV and SI between the two group （P 〉 0.05）. CONCLUSION Azelnidipine significantly reduces blood pressure in elderly patients with primary hypertension with smaller blood pressure fluctuation, and better than amlodipine in antihypertensive effect.

关 键 词：高血压 阿折地平 氨氯地平 血压变异性 

分 类 号：R544.1[医药卫生—心血管疾病]