二硫键A氧化还原酶样蛋白对脂联素的调控机制研究进展  

Progress of the disulfide bond-forming oxidoreductase A-like protein on the regulation mechanism of adiponectin

作　　者：刘旭东[1] 沈震[1] 时彩红[1] 邓鑫[1] 

机构地区：[1]广西中医药大学附属瑞康医院肝胆内科,广西南宁530011

出　　处：《胃肠病学和肝病学杂志》2014年第7期848-850,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金项目(81360596);广西自然科学基金课题(2012GXNSFAA053098);广西自治区教育厅项目(201204LX203)

摘　　要：近年来,二硫键A氧化还原酶样蛋白作为一个新发现的分子伴侣已被证实与脂联素的分泌、合成及多聚化各个环节关系密切。部分研究发现,二硫键A氧化还原酶样蛋白能够促进脂联素的表达,Akt/FOXO1和AMPK信号途径在该蛋白对脂联素的调控机制中可能起到了关键作用。进一步明确二硫键A氧化还原酶样蛋白调控脂联素的机制,对寻找治疗糖尿病、非酒精性脂肪肝等代谢紊乱疾病的新靶点具有重要意义。In recent years,the disulfide bond-forming oxidoreductase A-like protein as a new molecular chaperone has been confirmed associated with adiponectin secretion,synthesis and polymerization.Part of the research find that disulfide bond-forming oxidoreductase A-like protein can promote the expression of adiponectin.Akt/FOXO1 and AMPK signaling pathway may play key roles in the mechanism of the protein,regulation adiponectin.To further clarify the mechanism of the disulfide bond-forming oxidoreductase A-like protein,regulation of adiponectin is essential to explore a new target for the treatment of diabetes,nonalcoholic fatty liver and metabolic disorders diseases.

关 键 词：二硫键A氧化还原酶样蛋白 脂联素 调控机制 

分 类 号：R392[医药卫生—免疫学]