空腹血糖对中老年人群踝臂指数的影响  

Effect of Fasting Blood Glucose on Ankle-brachial Index in the Elderly Population

作　　者：李伟哲[1] 陈朔华 王艳秀[3] 刘占辉[4] 韩红锋[1] 孟令民[5] 孙玉艳[3] 赵性泉[6] 吴寿岭[3] 高明[3] 

机构地区：[1]河北联合大学研究生院,河北省唐山市063000 [2]开滦员工健康保障中心,河北省唐山市063000 [3]河北联合大学附属开滦总医院心内科,河北省唐山市063000 [4]河北医科大学第一医院放射科,河北省石家庄市050031 [5]河北联合大学附属开滦总医院急诊科,河北省唐山市063000 [6]首都医科大学附属天坛医院神经内科,北京市100020

出　　处：《中国动脉硬化杂志》2014年第8期845-850,共6页Chinese Journal of Arteriosclerosis

基　　金：国家科技支撑计划项目(2008BAI52B03)

摘　　要：目的探讨不同空腹血糖水平（FBG）对中老年人踝臂指数（ABI）的影响。方法在2006年-2007年参加健康体检的101510例开滦集团职工中随机分层抽取5852例作为研究对象,进行统一问卷调查及血液生化检查,符合入选标准的为5440例。于2010年-2011年进行第三次健康体检并测量ABI,最终纳入统计分析的有效数据为5189例。根据美国糖尿病协会指南,按FBG将研究人群分成三组：理想血糖组（FBG〈5.6 mmol/L）、空腹血糖受损（IFG）组（5.6 mmol/L≤FBG〈7.0 mmol/L）、糖尿病组（FBG≥7.0 mmol/L或糖尿病患者）。对影响ABI的相关危险因素进行多因素Logistic回归分析。结果理想血糖组、IFG组、糖尿病组ABI分别为1.10±0.09、1.09±0.11、1.08±0.13（P〈0.05）,ABI≤0.9的检出率分别为2.97%、4.74%、8.81%（P〈0.05）。多因素Logistic回归分析显示,糖尿病为ABI≤0.9的危险因素,其OR值为1.97（95%CI为1.32-2.96）;在女性人群中,IFG、糖尿病均为ABI≤0.9的危险因素,其OR值分别为2.26（95%CI为1.25-4.07）、2.37（95%CI为1.06-5.26）。结论空腹血糖是影响中老年人群ABI的独立危险因素,在女性人群中更加显著。Aim To investigate the effect of different fasting blood glucose（ FBG） levels on ankle-brachial index（ ABI） in the elderly population. Methods 101510 workers who had participated in Kailuan health examination in2006 - 2007 were stratified randomly,and 5440 participants with sufficient information for questionnaires and blood biochemical tests were recruited. ABI was tested in 2010 - 2011 Kailuan health examination,and 5189 were included for the final analysis. According to the American Diabetes Association guidelines,the study population was divided into three groups by FBG in 2010 - 2011 examination： ideal blood group（ FBG 5. 6 mmol /L）,impaired fasting glucose（ IFG）group（ 5. 6 mmol /L≤FBG 7. 0 mmol /L） and diabetes mellitus group（ FBG≥7. 0 mmol /L or diabetes mellitus patients）. Multivariate Logistic regression analysis were used to calculate the rate for ABI. Results ABI in different groups were 1. 10 ± 0. 09,1. 09 ± 0. 11 and 1. 08 ± 0. 13（ P〈0. 05）,the detection rates of ABI≤0. 9 in different groups were 2. 97%,4. 74% and 8. 81%（ P〈0. 05）. Multivariate Logistic regression analysis showed that diabetes mellitus was the risk factor for ABI≤0. 9,OR value was 1. 97（ 95% CI was 1. 32 - 2. 96）. In the female population,IFG and diabetes mellitus were risk factors for ABI≤0. 9,OR value was 2. 26（ 95% CI was 1. 25 - 4. 07） and 2. 37（ 95% CI was1. 06 - 5. 26）. Conclusion FBG is an independent risk factor for ABI,more pronounced in women.

关 键 词：空腹血糖 踝臂指数 外周动脉疾病 

分 类 号：R5[医药卫生—内科学]