基于MR扩散张量成像探讨胼胝体各向异性分数与年龄的关系  

Age-related changes in fractional anisotropy in corpus callosum with MR diffusion tensor imaging

作　　者：高燕军[1] 邬小平[1] 李建文[2] 李贤军[3] 孙东海[1] 杨军乐[1] 杨健[4] 

机构地区：[1]西安交通大学医学院附属西安市中心医院影像中心,710061 [2]宁夏石嘴山市第一人民医院放射科 [3]西安交通大学生命学院 [4]西安交通大学医学院第一附属医院影像中心

出　　处：《中华放射学杂志》2014年第7期535-538,共4页Chinese Journal of Radiology

基　　金：陕西省科技厅攻关项目（2008K11-02）

摘　　要：目的 分析胼胝体不同区域MR扩散张量（DTI）各向异性分数（FA）值随年龄的变化特点.方法 收集171名健康志愿者进行MR DTI扫描,其中男80名、女91名;年龄12 ～ 73岁,中位年龄44岁.按年龄段每10岁分为一组,分为10～ 19、20～29、30 ～ 39、40～49、50～59、60～69、70～79岁共7组,例数分别为2、32、33、54、35、11、4名.将胼胝体分为5个亚区（Ⅰ～Ⅴ区）,测量胼胝体各分区FA值,计算各年龄组不同胼胝体分区FA均值,利用曲线回归的方法分析其随年龄的变化特点.结果 在同年龄组中,胼胝体Ⅴ区FA均值最高,7组对应的FA值依次为0.77±0.06、0.80±0.03、0.79±0.03、0.79±0.03、0.78±0.03、0.77±0.03、0.77±0.03;胼胝体Ⅲ区FA值最低,7组FA值依次为0.51±0.08、0.59±0.06、0.59±0.06、0.56±0.07、0.55±0.07、0.52±0.07、0.43±0.07.胼胝体不同分区FA值与年龄呈曲线相关（ROI1～ROI5 R2值依次为0.162、0.214、0.164、0.098、0.070,P值均＜0.05）;随着年龄的增长,各分区FA值的变化呈近似倒U形趋势.各分区FA峰值出现在20 ～ 30岁.结论 胼胝体各区域扩散张量FA值随年龄增长呈曲线变化,反映了胼胝体随年龄的生理变化过程,可为相关研究提供参考.Objective To analyze age-related changes in fractional anisotropy（FA） in sub-regions of corpus callosum on diffusion tensor imaging（DTI）.Methods DTI was obtained from 171 healthy individuals（80 men,91 women; age 12 to 73 years; median age 44 years）.All the subjects were stratified into the following seven age groups（10-19,20-29,30-39,40-49,50-59,60-69,70-79 years）.Corpus callosum was divided into 5 subregions（Ⅰ-Ⅴ region）.DTI FA values of sub-regions of corpus callosum were measured.Mean FA values changes in corpus callosum sub-regions with advancing age were evaluated with hierarchical polynomial regression analyses.Results The mean FA value in the Ⅴ region was the highest within the same age group.The corresponding values from group 1 to 7 were 0.77±0.06,0.80±0.03,0.79±0.03,0.79±0.03,0.78±0.03,0.77±0.03,0.77±0.03,respectively.The mean FA value in the Ⅲ region was the lowest within the same age group.The corresponding values from group 1 to 7 were 0.51 ±0.08,0.59± 0.06,0.59±0.06,0.56±0.07,0.55±0.07,0.52±0.07,0.43±0.07,respectively.The change of FA values in subregions of the corpus callosum on DTI followed an inverted U-shaped curve with advancing age（ROI1-ROI5,R2=0.162,0.214,0.164,0.098,0.070,respectively,all P＜0.05）.FA peak appeared at 20 to 30 years old in all regions.Conclusions The study demonstrated age-related changes in FA value in sub-regions of the corpus callosum on DTI as following a curve,reflecting the age-related changes of physiological processes,which could serve as a basis for corpus callosum research.

关 键 词：胼胝体 磁共振成像 年龄因素 

分 类 号：R445.2[医药卫生—影像医学与核医学]