消风止嗽汤治疗咳嗽变异性哮喘随机平行对照研究  

Xiaofeng Zhisou Decoction in the Treatment of Cough Variant Asthma Randomized Parallel Controlled Study

作　　者：陈凤兰[1] 陈粉莲[1] 卢杰宁[1] 萧汉达[1] 邝宁子[1] 李轩[1] 

机构地区：[1]东莞市人民医院中医科,广东东莞523000

出　　处：《实用中医内科杂志》2014年第7期26-28,共3页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察消风止嗽汤治疗咳嗽变异性哮喘的疗效。[方法]使用随机平行对照方法,将76例住院及门诊患者按就诊顺序编号法随机分为两组。对照组38例必可酮气雾剂,100μg/次,2次/d;酮替芬,1mg/次,2次/d,1周后改为每晚1片。治疗组38例消风止嗽汤(荆芥12g,防风9g,蝉蜕6g,当归15g,白前12g,桔梗15g,百部l2g,紫菀15g,苍术12g,牛蒡子9g,甘草6g,紫苏子12g,炙麻黄6g),水煎300mL,1剂/d,早晚分服。连续治疗28d为1疗程。观测临床症状、外周血干扰素-γ(INF-γ)、白介素-4(IL-4)、不良反应。治疗1疗程,判定疗效。[结果]治疗组治愈16例,显效13例,有效6例,无效3例,总有效率92.11%。对照组治愈8例,显效10例,有效9例,无效11例,总有效率71.05%。治疗组疗效优于对照组(P<0.05)。[结论]消风止嗽汤治疗咳嗽变异性哮喘效果显著,值得推广。[Objective] To observe the clinical efficacy of Xiao feng Zhisou Decoction in treatment of cough variant asthma . [ Methods] Using random parallel control method, 76 eases of outpatient and hospitalized patients were randomly divided into two groups according to treatment order numbers. The control group 38 cases beelomethasone spray , 100 μg/times, 2times/d;and ketotifen, lmg/times, ltime/d, after 1 weeks to 1 tablets every night. The treatment group 38 cases Xiaofeng Zhisou decoction （ Jingjie 12g, Fangfeng 9g, Cantui 6g, Danggui 15g, Baiqian 12g, Jiegeng 15g, Baibul2g, Ziyuan 15g, Cangzhu 12g, niubangzi 9g, Gancao 6g, Zishuzi 12g, Zhimahuang 6g ）, ldose/d, boiling water 300ml, oral sooner or later.Continuous treatment of 28d a course of treatment. Observation of clinical symptoms, INF- γ and IL-4 of peripheral blood, adverse reactions.Treatment ltreatment, to judge the curative effect. [ Results ] In the treatment group, 16 cases were cured, 13 cases were markedly effective, 6 cases were effective, 3 cases were invalid, the total effective rate was 92.11%. In the control group, 8 cases were cured, 10 cases were markedly effective, 9 cases were effective, 11 cases were invalid, the total effective rate was 71.05 %o The total effective rate of treament group was better than the control group （ P〈0.05 ） . [ Conclusion ] Xiaofeng Zhisou de coction treatment of cough variant asthma effctct, is worth promoting.

关 键 词：消风止嗽汤 咳嗽变异性哮喘 必可酮气雾剂 细胞免疫 体液免疫 外周血干扰素-γ(INF-γ) 白介素-4(IL-4) 随机平行对照研究 

分 类 号：R725.622.5[医药卫生—儿科]