和肽素检测与心血管疾病  

C-terminal provasopressin measurement and cardiovascular disease

作　　者：沈絮华[1] 李虹伟[1] 马文英[1] 

机构地区：[1]首都医科大学附属北京友谊医院心脏中心,100050

出　　处：《中华检验医学杂志》2014年第7期493-496,共4页Chinese Journal of Laboratory Medicine

摘　　要：和肽素（ct-proAVP或copeptin）是一种新型的下丘脑和神经垂体中的神经激素.由于其结构和检测方法的优势逐渐取代抗利尿激素,被视为非特异性应激反应的一个重要标志,近年来ct-proAVP的检测逐渐受到临床的关注,尤其在心血管疾病（心力衰竭和急性冠状动脉综合征等）.本文阐述了ct-proAVP的检测优势、方法以及其在各种心血管疾病中的临床价值.Copeptin, the C-terminal portion of provasopressin, is a novel neurohormone of the arginine vasopressin （AVP）system, and is known to be co-released with AVP from hypothalamus. As a surrogate marker of the AVP system, copeptin has gradually replaced AVP in several clinical studies largely due to its structural and methodological advantages. Copeptin has been regarded as a marker of non-specific stress response. In recent years, copeptin attracts more and more attention especially in cardiovascular conditions （heart failure and acute coronary syndromes ）. The present review primarily focuses on eopeptin detection, its general advantages, and its potential clinical value in a variety of cardiovascular conditions.

关 键 词：糖肽类 心血管疾病 生物学标记 

分 类 号：R54[医药卫生—心血管疾病]