Gene mapping of serotoninergic system polymorphisms provides insight on pathology and treatment of men with lifelong premature ejaculation  

作　　者：Theodore R Saitz Ege Can Serefoglu 

机构地区：[1]Departments of Urology, Oregon Health and Science University, Portland, Oregon, USA [2]Urology, Bagcilar Training and Research Hospital, IstanbuI, Turkey.

出　　处：《Asian Journal of Andrology》2014年第4期643-643,共1页亚洲男性学杂志（英文版）

摘　　要：In spite of its long history and high prevalence, the exact pathophysiology of premature ejaculation （PE） remains to be unknown？ Over a decade ago, Waldinger et al.2 initially suggested that hypersensitivity of 5-HT1A receptors and/or hypofunction of 5-HT2c receptors might be responsible for this phenomenon; thus, the daily use of a selective serotonin reuptake inhibitor has now emerged as an effective treatment for delaying ejaculation.In spite of its long history and high prevalence, the exact pathophysiology of premature ejaculation （PE） remains to be unknown？ Over a decade ago, Waldinger et al.2 initially suggested that hypersensitivity of 5-HT1A receptors and/or hypofunction of 5-HT2c receptors might be responsible for this phenomenon; thus, the daily use of a selective serotonin reuptake inhibitor has now emerged as an effective treatment for delaying ejaculation.

分 类 号：Q255[生物学—细胞生物学] Q517