HIV合并HCV感染者早期肝硬化的肝脏CT灌注成像  

The CT Perfusion Imaging of Liver in Patients with Early Cirrhosis with HIV/HCV Co-infected

作　　者：江松峰[1] 刘晋新[1] 陈碧华[1] 凌洲焜[1] 梁艺[1] 丁岩[1] 

机构地区：[1]广东省广州市第八人民医院放射科,广东广州510060

出　　处：《中国CT和MRI杂志》2014年第4期26-28,共3页Chinese Journal of CT and MRI

基　　金：HIV合并HCV感染者肝脏CT灌注成像的研究(广东省医学科研基金立项);编号:A2012517

摘　　要：目的探讨肝脏CT灌注成像对HIV合并HCV感染者早期肝硬化诊断的应用价值。方法对33例HIV感染并慢性丙型肝炎患者行肝脏CT灌注扫描,其中早期肝硬化组14例、非肝硬化组19例;对两组的各项灌注参数进行对比分析。结果早期肝硬化组与非肝硬化组对比,门静脉灌注量(HPP)、门静脉灌注指数(PPI)、肝脏总灌量(TLP)明显降低[HPP:(86.34±20.73)ml·min-1·100ml-1与(111.87±20.59)ml·min-1·100ml-1,P=0.0014;PPI:(72.18±2.94)%与(78.69±2.29)%,P=0.0001;TLP:(119.44±27.17)ml·min-1·100ml-1与(142.02±24.70)ml·min-1·100ml-1,P=0.0001],而肝动脉灌注指数(HPI)明显升高[(27.82±2.94)%与(21.31±2.29)%,P=0.0001];以上4项灌注参数在两组间的差异有统计学意义。结论肝脏CT灌注成像能反应HIV合并HCV早期肝硬化的血流灌注改变,对临床的早期诊断和治疗有重要价值。Objective To evaluate the value of CT perfusion imaging of liver in diagnosis of the early cirrhosis in patients with HIV/HCV co-infected. Methods The CT perfusion scans of liver were tested for 33 patients with chronic hepatitis C and HIV-infected,including 14 patients with early cirrhosis and 19 patients with non-cirrhosis;parameters of the CT perfusion were compared wih two groups. Results Compared to non-cirrhosis group,HPP、PPI and TLP with patients in early cirrhosis were significant lower[HPP： （86.34±20.73）ml·min-1·100ml-1 vs （111.87±20.59） ml·min-1·100ml-1,P=0.0014; PPI：（72.18±2.94）% vs （78.69±2.29）%,P=0.0001;TLP：（ 119.44±27.17）ml·min-1·100ml-1 vs （142.02±24.70）ml·min-1·100ml-1,P=0.0185], whereas their HPI were significant higher[（27.82±2.94）%vs （21.31±2.29）%,P=0.0001]. There was significant difference of the four parameters of the CT perfusion between early cirrhosis and non-cirrhosis. Conclusion The CT perfusion of liver could reflect the variation of blood flow in the patients with early cirrhosis which was co-infected with HIV/HCV.Furthermore it could be detected for early clinical diagnosis and treatment.

关 键 词：人类免疫缺陷病毒 丙型肝炎病毒 肝硬化 灌注成像 体层摄影术 X线计算机 

分 类 号：R657.31[医药卫生—外科学] R445.3[医药卫生—临床医学]