婴幼儿亲属活体肝移植后巨细胞病毒感染的临床分析  

Cytomegalovirus infection after infants living related liver transplantations

作　　者：邢雨[1] 张建军[2] 蔡金贞[2] 郑虹[2] 邓永林[2] 潘澄[2] 蒋文涛[2] 高伟[2] 杨涛[2] 王政禄[2] 

机构地区：[1]天津医科大学一中心临床学院,300070 [2]天津市第一中心医院东方器官移植中心

出　　处：《中华器官移植杂志》2014年第7期405-407,共3页Chinese Journal of Organ Transplantation

基　　金：国家高技术研究发展计划（2012AA021001）;公益性行业科研专项（201302009）;国家自然科学基金（81170443）

摘　　要：目的 探讨婴幼儿亲属活体肝移植后巨细胞病毒（CMV）感染的诊断、预防和治疗.方法 采用回顾性分析的方法,分析2012年1月至2013年7月期间进行的67例亲属活体肝移植,术后给予更昔洛韦＋阿昔洛韦预防CMV感染,并对患儿进行血清CMV DNA检测.结果 术后19例发生CMV感染,其中3例出现发热（其中1例合并血细胞减低）,3例出现肺部感染（其中1例合并真菌感染,1例合并血细胞减低）,13例无症状,而经更昔洛韦治疗后患儿血清CMV DNA转为阴性.结论 在均采取预防情况下,婴幼儿亲属活体肝移植后CMV感染率高于成人,更昔洛韦能够有效的治疗婴幼儿亲属活体肝移植后CMV感染,婴幼儿亲属活体肝移植后积极预防和早期治疗CMV感染至关重要.Objective To investigate diagnosis,prevention and treatment of cytomegalovirus （CMV） infection after infants living related liver transplantations.Method The clinical data of 67 infants living related liver transplantations in our hospital from January 2012 to July 2013 were retrospectively analyzed.Ganciclovir and acyclovir were given for prophylaxis of CMV infection after surgery.Result CMV infection occurred in 19 patients：3 of them presented with fever （1 with reduced number of blood cells）,3 with lung infection （1 with merger fungal infection,and 1 with reduced number of blood cells）,and 13 patients had no symptoms of CMV infection.Blood CMV-DNA became negative by treatment with ganciclovir.Conclusion The incidence of CMV infection in infants living related liver transplantations was higher than adults after taking the preventive treatment.Ganciclovir was effective for treatment of CMV infection and it was very important about treatment and prevention of CMV infection after biliary atresia infants living related liver transplantations.

关 键 词：活体肝移植儿 巨细胞病毒感染 胆道闭锁 

分 类 号：R726.5[医药卫生—儿科]