帕瑞昔布钠预处理对异丙酚注射痛的影响  

Effect of Pretreatment with Parecoxib on Ropofol Injection Pain

作　　者：曹振刚[1] 张建丽[1] 张淑芳[1] 古昌剑 张新峰[1] 彭深渠[1] 孙明明[1] 李新成[1] 

机构地区：[1]新疆生产建设兵团第一师医院麻醉科,新疆阿克苏843000

出　　处：《新疆医学》2014年第6期9-11,共3页Xinjiang Medical Journal

摘　　要：目的：观察静脉预先注射不同剂量的帕瑞昔布钠后阻断静脉与不阻断静脉对异丙酚注射痛的影响.方法：将择期行各类手术的ASA分级Ⅰ或Ⅱ级（年龄20～60岁,性别不限）的患者150例根据随机数字表随机的分为5组,每组30例.P1组：将静脉血管在其近心端阻断后静注帕瑞昔布钠40mg,1min后解除阻断,开始TCI异丙酚;P2组：直接静脉注射40mg帕瑞昔布钠1min后TCI异丙酚;P3组：阻断静脉后静注帕瑞昔布钠20 mg,1min后解除阻断,开始TCI异丙酚;P4组：直接静脉注射20mg帕瑞昔布钠1min后TCI异丙酚;P5组：静注生理盐水4ml 1min后TCI异丙酚.在患者意识完全消失前询问注射异丙酚时血管疼痛情况,统计注射痛的发生率.结果：各组患者一般资料无差异（P＞0.05）;P4组、P5组注射痛的发生率高于P1组（P＜0.001）,而P2组、P3组注射痛发射率与P1组差异无统计学意义（P＞0.05）;P2组与P3组注射痛发生率差异无统计学意义（P＞0.05）,但P4组、P5组注射痛发生率高于P2组（P＜0.05）;P4组、P5组注射痛发射率高于P3组（P＜0.05）;P4组与P5组注射痛发射率差异无统计学意义（P＞0.05）.结论阻断静脉后预先静注20mg的帕瑞昔布钠或直接静脉注射40mg帕瑞昔布钠可有效的降低异丙酚引起的注射痛发生率.Objective： To investingate the effect of pretreatment with different dose Parecoxib on propofol injec- tion pain. Methods The study was a prospective, randomized and doubleblind study, One hundred and fifty patients （20-60 years of age, regardless of gender ）, ASAclass I orⅡ, scheduled to undergo elective surgery, were randomly divided into five group by stable of random number, thirty patients each group. Five groups of patients were generated： group P1 and group P3 received arecoxib 40mg and 20rag in 4ml normal saline （NS） with venous occlusion （VO） and removed VO after 60s and subsequent injected propofol; group P2 and group P4 received pareeoxib 40rag and 20rag in 4ml NS and propofol was injected after 60s ;group P5 received NS 4ml i.v. ;The pain perception was assessed dur- ing injection of propofol in all patients. Result There were no signific differenc（P〉0.05） in the patient＇s age, gender, BMI and ASA class among each group. Incidence of propofol injection pain ： in group P1 was significantly lower than in group P4 and group P5 （P〈0.001）, there was no significantdifference between group P2, group P3 and group P1 （P〉0.05）; there was no significantdifference between group P2 and group P3（P〉O.05）, in group P2 was lower than in group P4 and group PS（P〈0.05）; In group P3 was lower than in group P4 and group PS（P〈0.05）; There was no sig- nificantdifference.between group P4 and group P5 （P〉0.05）. Conclusion Pretreatment with i.v. parecoxib 20mg with VO and i.v. parecoxib 40mg directly after 60s injected propofol achieves the same pain relief effect, the incidence of pain following propofol iniection was reduced.

关 键 词：异丙酚 帕瑞昔布钠 剂量 预处理 静脉注射痛 

分 类 号：R452[医药卫生—治疗学]