动物肠道黏膜抗菌肽维持微生物区系平衡机制研究进展  

Research Progress of the Mechanism of Antibacterial Peptide in Animal Intestinal Mucosa Maintaining Microbial Flora Balance

作　　者：蔡杰[1] 唐志如[1] 邓欢[1] 孙志洪[1] 赖星[1] 

机构地区：[1]西南大学动物科技学院生物饲料与动物营养重点实验室,重庆 400715

出　　处：《动物营养学报》2014年第8期2071-2076,共6页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家973重点基础研究发展计划项目(2013CB127303);重庆市自然科学基金(cstc2012jjA80001);中央高校基本业务费专项资金(XDJK2014B028);国家循环农业项目(2012BAD14B18)

摘　　要：肠道微生物与宿主形成共生关系,在维持机体健康的同时,也能对机体造成伤害。肠道抗菌肽是一类对抗外源性病原体致病作用的防御性肽类活性物质,由肠道细胞合成或被分泌到肠道,包括防御素(defensins)、cathelicidins(如LL-37)、C型凝集素[如再生胰岛衍生蛋白(REG)家族]、核糖核酸酶(RNases)和S100蛋白(如钙卫蛋白),参与维持动物肠道微生物区系的平衡。本文综述了动物肠道黏膜抗菌肽维持微生物平衡的作用及其机制。The gut microbiota form a symbiotic relationship in human and animals,which keep the gut and the host healthy as well as cause potential damage. Antimicrobial peptides of intestinal mucosa synthesized or secre-ted by intestinal cells are a kind of defensive peptides against the pathogenicity of exogenous pathogens. The an-timicrobial peptides of intestinal mucosa,including defensins,cathelicidins（ e. g. LL-37 ）,C-type lectins （ such as the regenerating islet-derived protein family）,ribonucleases（ RNases）and S100 proteins（ e. g. cal-protectin）,are involved in the maintenance of animal intestinal microflora balance. This paper reviewed the effect and mechanism of the animal intestinal mucosal antimicrobial peptides in maintaining microbial flora balance.

关 键 词：肠道黏膜 抗菌肽 防御素 肠道微生物 

分 类 号：S811.2[农业科学—畜牧学]