丙泊酚靶控输注复合舒芬太尼在无痛胃肠镜中的应用  

Conferring of TCI of propofol combined sufentanil in patients undergoing electronic endoscopy

作　　者：孙剑[1] 蔡捍东[1] 赵志丹[1] 

机构地区：[1]首都医科大学附属复兴医院麻醉科,北京100038

出　　处：《中国医刊》2014年第8期52-54,共3页Chinese Journal of Medicine

摘　　要：目的：探讨丙泊酚靶控输注（TCI）配伍小剂量舒芬太尼在无痛胃肠镜麻醉中的效应室浓度。方法择期行无痛胃肠镜患者80例,ASAⅡ~Ⅲ级,根据年龄分为4组（每组 n=20）即：40岁以下组、41~60岁组、61~80岁组以及80岁以上组。分别观察各组患者从注射丙泊酚即刻到意识消失时丙泊酚效应室浓度,胃肠镜操作过程中丙泊酚效应室浓度,停止输注丙泊酚即刻到患者睁眼的时间、定向力恢复的时间。结果各组患者意识消失时,丙泊酚效应室浓度差异无显著性（P〉0.05）；各组患者在胃肠镜操作中,丙泊酚效应室浓度随着年龄的增长逐渐降低（P〈0.05）；各组患者停止输注丙泊酚即刻到其睁眼时间、定向力恢复时间差异无显著性（P〉0.05）。结论无痛胃肠镜检查中,复合小剂量舒芬太尼的丙泊酚效应室浓度随着年龄的增长逐渐降低。Objective To investigate the target effect-site concentration of propofol （target concentration injection） with sufentanil in patients undergoing diagnostic gastrointestinal endoscopy. Method Eighty patients （ASA from Ⅱto Ⅲ）, scheduled undergoing gastrointestinal endoscopy were divided into 4 groups （ n = 20 twenty patients per group）： younger than 40 group, age between 41 to 60 group, age between 61 to 80 group, and older than 80 group. Observation of target effect-site concentration of propofol when the patients loss of conscious and endoscopic opera-tion, wake-up time, time of comeback of directional ability were also recorded. Result The target effect-site concen-tration of propofol were no statistical difference, when the patients loss of conscious（P〉0. 05）. In the endoscopic operation process, the target effect-site concentration of propofol decreased with aging（P〈0. 05）. Wake-up time, and time of comeback of directional ability were no statistical difference from stop injection（P〉0. 05）. Conclusion In the endoscopic operation process, the target effect-site concentration of propofol decreased with aging.

关 键 词：丙泊酚 靶控输注 无痛胃肠镜 

分 类 号：R614[医药卫生—麻醉学]