Synthesis of 5-functionalized-1,2,3-triazoles via a one-pot aerobic oxidative coupling reaction of alkynes and azides  

作　　者：Ling-Jun Li Yu-Qin Zhang Yang Zhang An-Lian Zhu Gui-Sheng Zhang 

机构地区：[1]School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education,Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Henan Normal University

出　　处：《Chinese Chemical Letters》2014年第8期1161-1164,共4页中国化学快报（英文版）

基　　金：the NSFC (Nos. 21172058, 20802017);HASTIT (No. 2012HASTIT10);PCSIRT (No. IRT1061);Key Technologies R & D Program of Henan Province (No. 112102310319) for financial support

摘　　要：In this paper, an efficient synthesis of 5-alkynyl-1,2,3-triazoles through a one-pot aerobic oxidative coupling reaction of various alkynes and azides has been developed. Further derivatization of 5-alkynyl-1,2,3-triazoles readily yielded 5-carbonyl-1,2,3-triazoles, 5-carboxylic-1,2,3-triazole, 5-hydroxyalkyl-1,2,3-triazoles and 5-quinoxaline-1,2,3-triazole, which provided an entry into structurally diverse 5-functionalized-1,2,3-triazoles.In this paper, an efficient synthesis of 5-alkynyl-1,2,3-triazoles through a one-pot aerobic oxidative coupling reaction of various alkynes and azides has been developed. Further derivatization of 5-alkynyl-1,2,3-triazoles readily yielded 5-carbonyl-1,2,3-triazoles, 5-carboxylic-1,2,3-triazole, 5-hydroxyalkyl-1,2,3-triazoles and 5-quinoxaline-1,2,3-triazole, which provided an entry into structurally diverse 5-functionalized-1,2,3-triazoles.

关 键 词：ALKYNE AZIDE 1 2 3-TRIAZOLE Copper catalysis 

分 类 号：O621.3[理学—有机化学]