Microwave irradiation: Novel and facile methods for the synthesis of new pyrimidinones  

作　　者：Aida Chaker Fathi Zribi Franoise Nepveu Fakher Chabchoub 

机构地区：[1]Department of Chemistry, University of Sfax, Road Soukra km 4-3000 Sfax,Tunisia [2]UPS, UMR 152 PHARMA-DEV, University of Toulouse III, 118 road of Narbonne, F-31062 Cedex 9 Toulouse, France [3]Department of Chemistry, University of Sfax, Road Soukra km 4-3000 Sfax, Tunisia [4]IRD, UMR 152, F-31062 Cedex 9 Toulouse, France

出　　处：《Chinese Chemical Letters》2014年第8期1207-1210,共4页中国化学快报（英文版）

基　　金：the Ministry of Higher Education, Scientific Research and Technology of Tunisia and the University of Toulouse III for financial support

摘　　要：We describe here a rapid process for the preparation of new 9-chloromethyl-12-aryl-10,12-dihydrobenzo[5,6]chromeno[2,3-d]pyrimidin-11-ones 5a-d and 10-chloromethyl-7-aryl-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-ones 6a-d by two different methods utilizing microwave irradiation. This methodology provides better yields（72%–80%） and high purity of the title compounds.We describe here a rapid process for the preparation of new 9-chloromethyl-12-aryl-10,12-dihydrobenzo[5,6]chromeno[2,3-d]pyrimidin-11-ones 5a-d and 10-chloromethyl-7-aryl-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-ones 6a-d by two different methods utilizing microwave irradiation. This methodology provides better yields（72%–80%） and high purity of the title compounds.

关 键 词：MICROWAVE-IRRADIATION Aminonitriles naphtopyraniques Chloroacetylchloride PYRIMIDINONES 

分 类 号：O626.41[理学—有机化学]