肾脏发育进化与组织再生  

Renal development and regeneration

作　　者：张炯[1] 刘志红[1] 

机构地区：[1]南京军区南京总医院国家肾脏疾病临床医学研究中心全军肾脏病研究所,南京210016

出　　处：《肾脏病与透析肾移植杂志》2014年第3期252-259,共8页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：肾脏损伤后的修复分为瘢痕修复和再生修复,肾脏再生又分为细胞再生和肾单位再生。人类肾脏仅遗传保留了局部细胞水平再生,不具备低等生物肾单位整体组织结构功能的重建。近年来,大量研究证实,肾脏祖细胞参与了疾病和健康状态时的肾脏再生过程。本文介绍人类及哺乳类动物肾脏的发育进化,了解物种进化中肾脏的发育过程;介绍肾脏祖细胞随进化发展在不同物种间的区别,阐述高等生物肾脏祖细胞参与的细胞再生机制特点。Following the kidney injury, the repair can result in functional tissue becoming a patch of cells and disorganized extracellular matrix, or it can recapitulate the original tissue architecture through the process of regeneration. The kidney regeneration has cellular regeneration, which is conserved in all animal species from the ancestral phases of evolution. Another type of regenerative response is nephron neogenesis, which does not occur in adult mammals including human. The converging evidence suggests that a renal progenitor system is present in the adult kidney across different stages of evolution. In this review, we will describe the similarities and differences between the renal progenitor regeneration systems through evolution. Understanding the mechanisms that drive renal progenitor growth and differentiation represent the key step for modulating this potential for therapeutic purposes.

关 键 词：干细胞 祖细胞 哺乳动物 肾单位 修复 

分 类 号：R692[医药卫生—泌尿科学]