巨噬细胞活化表型与肾脏疾病  

Different activation phenotype macrophages in renal disease

作　　者：郭银凤[1,2] 张晓良[1,2] 

机构地区：[1]东南大学附属中大医院肾脏内科 [2]东南大学肾脏病研究所,南京210009

出　　处：《肾脏病与透析肾移植杂志》2014年第3期260-264,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然科学基金(81370826);江苏省十二五医学重点人才项目(RC2011124);中央高校基本科研业务费专项基金(CXLX13-122)

摘　　要：巨噬细胞在肾组织的浸润及活化,在慢性肾脏病发生发展中发挥重要作用。巨噬细胞是一种异质性细胞,不同的活化表型发挥不同的生物学效应。M1型活化具有促炎及促纤维化作用,而M2型活化可能发挥抗纤维化及促进组织修复作用。本文就巨噬细胞的活化状态在肾脏疾病中作用的新进展进行综述,并展望通过调节巨噬细胞功能来治疗肾脏疾病的前景。Macrophage infiltration and activation plays an important role in the progression of chronic kidney diseases（CKD） .Macrophages comprise a heterogeneous population of cells.Different activation phenotype macrophages play different function.M 1 phenotype macrophages promote tissue inflammation and fibrosis, however M2 phenotype macrophages may play anti-fibrotic function and promote tissue repair. The present review provides an in-depth account of the role of activation phenotype macrophages in progression of CKD, and looks forward to using regulation of macrophage function as a tool to treat kidney diseases in the future.

关 键 词：肾脏疾病 巨噬细胞 

分 类 号：R692[医药卫生—泌尿科学]