MLKL regulates necrotic plasma membrane permeabilization  

作　　者：Lorenzo Galluzzi 

机构地区：[1]Gustave Roussy, Villejuif France [2]Universite Paris Descartes/Paris V, Sorbonne Paris Cite, Paris, France [3]Equipe 11 labellisee Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France [4]INSERM, U848, Villejuif France [5]Metabolomies and Cell Biology Platforms, Gustave Roussy, Villejuif France [6]Pole de Biologie, Hopital Europeen Georges Pompidou, AP-HP, Paris, France

出　　处：《Cell Research》2014年第2期139-140,共2页细胞研究（英文版）

摘　　要：Recent data from two independent laboratories have shed new light on the molecular mechanisms by which mixed lineage kinase domainlike （MLKL） promotes a peculiar form of regulated necrosis known as necroptosis. Upon phosphorylation by receptor-interacting protein kinase 3 （RIPK3）, MLKL appears indeed to form oligomers that localize to the plasma membrane and compromise its ability to preserve ionic homeostasis.

关 键 词：细胞膜通透性 坏死 蛋白激酶 分子机制 相互作用 平衡能力 实验室 新光源 

分 类 号：Q2[生物学—细胞生物学] S435.121.4[农业科学—农业昆虫与害虫防治]