Stereotyped distribution of midbody remnants in early C. elegans embryos requires cell death genes and is dispensable for development  

作　　者：Guangshuo Ou Christian Gentili Pierre Gonczy 

机构地区：[1]National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China [2]Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100101, China [3]Swiss Institute for Experimental Cancer Research (1SREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne CH-1015, Switzerland

出　　处：《Cell Research》2014年第2期251-253,共3页细胞研究（英文版）

基　　金：GO, CG and PG designed the project and analyzed the data; GO performed most experiments and prepared the figures; CG performed experiments, prepared the figures and movies; GO and PG wrote the manuscript. We thank Virginie Hachet and Fernando R Balestra for useful comments on the manuscript, as well as Michael Glotzer for the gift of ZEN-4 antibodies. We also thank Olivier Burri and Romain Guiet from the Bioimaging and Optics Platform （BIOP） at EPFL for their help with elaboration of movies. This work was supported by a grant to GO and PG from the Sino Swiss Science and Technology Cooperation （SSTC_ EG09_092011）, and grants from the National Basic Research Program （2012CB945002 and 2013CB945600） and the National Natural Science Foundation of China （31222035, 31190063 and 31171295）.

摘　　要：Dear Editor, The midbody is a structure formed within the inter- cellular bridge towards the end of cytokinesis [ 1 ]. Microtubules within this bridge are then severed on one side of the midbody during abscission, thus generating a midbody remnant in one of the resulting daughter cells. Midbody remnants persist long after cell division and ac- cumulate preferentially in stem cells, induced pluripotent stem （iPS） cells, and cancer stem cells [2-4]. Upon in- duction of differentiation, midbody remnants are degrad- ed by autophagy or released into the extracellular milieu in some tissue culture cells, and it has been proposed that such removal is critical for enabling a differentiation pro- gram [2-4]. However, the fate of midbody remnants in a developing organism remains elusive, and whether their presence plays a role in cell fate determination in vivo is not known.

关 键 词：细胞死亡 中间体 残余 多能干细胞 基因 分配 胚胎 线虫 

分 类 号：Q251[生物学—细胞生物学] TQ460.4[化学工程—制药化工]