MicroRNA-155 broadly orchestrates inflammation-induced changes of microRNA expression in breast cancer  

作　　者：Song Hu Wei Zhu Ling-Fei Zhang Ming Pei Mo-Fang Liu 

机构地区：[1]Center for RNA Research, State Key Laboratory of Molecular Biology, University of Chinese Academy of Sciences, Shanghai 200031, China [2]Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China [3]Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China [4]Shanghai Qibao High school, Shanghai 201101, China

出　　处：《Cell Research》2014年第2期254-257,共4页细胞研究（英文版）

基　　金：This work was supported by grants from the Ministry of Science and Technology of China （2011CB811303, 2012CB910802, 2014CB964802） and the National Natural Science Foundation of China （91219306, 31270840, 31170754, 30970621）.

摘　　要：Dear Editor, During the last decades, a number of key mediators of inflammation-induced tumorigenesis have been identified to support tumor progression in response to inflammation stimulation [1]. Recent studies show that a few cancerrelated microRNAs （miRNAs） are modulated by inflammation signals [2, 3], implicating miRNAs as a new class of mediators between inflammation and cancer. However, how inflammation regulates miRNAs in cancer cells and how such miRNA mediators function in inflammationassociated tumorigenesis remain largely unexplored.

关 键 词：MICRORNA 炎症 乳腺癌 miRNA 编排 肿瘤发生 RNA介导 信号调制 

分 类 号：Q522[生物学—生物化学] Q51