The ubiquitin conjugating enzyme UBE2L3 regulates TNFa-induced linear ubiquitination  

作　　者：Bishi Fu Shitao Li Lingyan Wang Michael A Berman Martin E Dorf 

机构地区：[1]Division of Immunology, Department of Microbiology and Immunobiol-ogy, Harvard Medical School, Boston, MA 02115, USA

出　　处：《Cell Research》2014年第3期376-379,共4页细胞研究（英文版）

摘　　要：The inducible and reversible modification of proteins with polyubiquitin chains has emerged as one of the most common and versatile means of protein modification. Ubiquitin contains 7 lysine residues, each of which can serve as an acceptor site for formation of polyubiquitin chains. In addition, the C-terminal glycine of one ubiquitin molecule can form a conventional peptide bond with the N-terminal methionine of an acceptor ubiquitin,

关 键 词：泛素化 肿瘤坏死因子 诱导 结合酶 蛋白质修饰 线性 调控 遍在蛋白 

分 类 号：Q26[生物学—细胞生物学] Q78