Notch和Wnt信号通路对神经干细胞增殖分化的影响  

The influence of Notch and Wnt signal pathways on the proliferation and differentiation of neural stem cells

作　　者：韩羽楠[1] 王振宇[2] 

机构地区：[1]中国医科大学 [2]中国医科大学基础医学院人体解剖学教研室,辽宁沈阳110001

出　　处：《解剖科学进展》2014年第4期385-387,389,共4页Progress of Anatomical Sciences

基　　金：辽宁省科技厅社会发展攻关计划(No.2012225021)

摘　　要：Notch和Wnt信号通路是调节神经干细胞(neural stem cells,NSCs)增殖、分化的重要通路,Notch信号通路的靶基因Hes1、Hes5及HES相关蛋白等分化抑制信号,通过旁侧抑制机制阻止NSCs的分化,并促进其自我更新;通过NICD与CSL DNA结合蛋白的直接结合,形成GFAP的转录激活复合物,上调GFAP的表达,从而促进NSCs向星形胶质细胞的分化。Wnt信号通过Wnt/β-catenin信号通路对细胞周期素D1和D2的转录调节,调控NSCs细胞周期的进程,使其量增殖;然而,过表达的Wnt3a和Wnt7a蛋白能够抑制NSCs的增殖,促进NSCs向神经元方向分化。Notch and Wnt signal pathways are both important for regulation of the proliferation and differentiation of neural stem cells（NSCs）. Notch target genes, Hes1, Hes5, and HES related protein and other differentiation inhibitory signals can stop the differentiation of NSCs through the side inhibition mechanism, and promote their self-renew; they can up-regulate the expression of GFAP and promote the differentiation of NSCs into astrocytes through the direct combination of NICD and CSL DNA binding proteins. Wnt signaling regulates cyclin D1 and D2 through the Wnt/beta-catenin signaling pathway, and regulates the process of NSCs cell cycle and increases the quantity of NSCs; the overexpression of Wnt3a and Wnt7a can inhibit the proliferation of NSCs, at the same time, they can induce NSCs into neurons.

关 键 词：Notch信号通路 WNT信号通路 细胞增殖分化 神经干细胞 Wnt β-catenin 细胞周期素D1 DNA结合蛋白 NSCS 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]