The lock-washer： a reconciliation of the RIG-I activation models  

作　　者：Shu Zhu Ruaidhri Jackson Richard A Flavell 

机构地区：[1]Department of lmmunobiology, Howard Hughes Medical Institute, Yale Universi, New Haven, CT 06520, USA

出　　处：《Cell Research》2014年第6期645-646,共2页细胞研究（英文版）

摘　　要：RIG-I belongs to a type of intracellular pattern recognition receptors involved in the recognition of viral RNA by the innate immune system. A report by Peisley et al. published in Nature provides the crystal structure of human RIG-I revealing a tetrameric architecture of the RIG-I 2-CARD do main bound by three K63-1inked ubiquitin chains, uncovering its activation mechanism for downstream signaling.

关 键 词：激活机制 模型 垫圈 模式识别 免疫系统 晶体结构 体系结构 锁 

分 类 号：Q26[生物学—细胞生物学] TP317.1[自动化与计算机技术—计算机软件与理论]