Structural insights into the TRIM family of ubiquitin E3 ligases  

作　　者：Yang Li Han Wu Wei Wu Wei Zhuo Weixiao Liu Yixiao Zhang Minzhang Cheng Ye-Guang Chen Ning Gao Hongtao Yu Linfang Wang Wei Li Maojun Yang 

机构地区：[1]MOE Key Laboratory of Protein Sciences, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China [2]Department of Pharmacology and Pharmaceutical Sci- ences, School af Medicine, Tsinghua University, Beijing 100084, China [3]State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College. Tsinghua University, Beo'ing 100005, China [4]State Key Laboratoty Reproductive Biology. Institute of Zoology, Chinese Acade- my of Sciences, Beo'ing 10010l, China [5]Howard Hughes Medical Institute. Department of Pharmaeology, University of Texas Southwestern Medical Center. Dallas. TX 75390. USA

出　　处：《Cell Research》2014年第6期762-765,共4页细胞研究（英文版）

基　　金：We thank Shilong Fan and the staffat the SSRF BL17U beamline for their assistance in data collection. We thank Jijie Chai and Yigong Shi from Tsinghua University for critical reading of the manuscript. This work was supported by the National Basic Research Program of China （973 Program; 2011CB910502, 2012CB911101 and 2011 CB944302）, the National Natural Science Foundation of China （31030020 and 31170679） and the State Key Laboratory Special Fund （2060204）.

摘　　要：TRIM proteins play important roles in a wide range of biological processes, including cell proliferation, dif- ferentiation, development, apoptosis, oncogenesis and innate immunity [1, 2]. The N-terminal regions of all TRIM proteins contain a RING finger domain followed by one or two B-box domains and a coiled-coil domain （CCD）. The RING-finger domain comprises conserved cysteine and histidine residues that bind two zinc atoms in a ＇cross-brace＇ arrangement, and is essential for recruiting the ubiquitin-charged ubiquitin-conjugating enzymes （E2-Ub）.

关 键 词：泛素 TRIM 连接酶 结构洞 家族 生物学过程 组氨酸残基 结构域 

分 类 号：Q51[生物学—生物化学] TN948.48[电子电信—信号与信息处理]