心肌兴奋-收缩偶联在心力衰竭中的研究进展  

Progress on excitation-contraction coupling in heart failure

作　　者：李青[1] 李菊香[1] 

机构地区：[1]南昌大学第二附属医院心内科,江西南昌330006

出　　处：《基础医学与临床》2014年第8期1129-1132,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(81060013);江西省自然科学基金(2010GZY0254)

摘　　要：心肌兴奋-收缩偶联(ECC)是心脏电活动转换成机械收缩的过程,Ca2+释放通道(RyR2)在ECC中起核心作用。Ca2+和Na+转运参与ECC的全过程。Ca2+转运蛋白和细胞内激酶与心力衰竭的发生发展密切相关,Ca2+转运的改变常发生在心功能衰竭之前。Ca2+转运与Na+转运相互影响,细胞内Na+转运因细胞内Na+浓度和晚钠电流增加而受到干扰,舒张期Ca2+持续增加导致舒张功能障碍,并诱导心律失常。Excitation-contraction coupling is the process by which the cardiomyocyte translates electrical excitation into mechanical contraction. The RyR2 plays a central role in the process. Ca^2＋ -handling and Na ^＋ -handling participate the whole process of excitation-contraction coupling. Alterations in Ca^2＋ -handling proteins and intracellular kinases are involved in the pathogenesis of heart failure. Changes in Ca^2＋ -handling often precede the depression of myocardial function. Intracellular Ca^2＋ -handling is closely coupled with intracellular Na^＋-handling. Intracellular Na^＋ -handling is disturbed with elevated intracellular Na^＋ -concentration and increased late INa. Diastolic Ca^2＋ can consecutively increase contributing to diastolic dysfunction and heart failure as well as arrhythmias.

关 键 词：兴奋-收缩偶联 钙 钙调蛋白依赖性蛋白激酶 钙转运 钠转运 

分 类 号：R541.6[医药卫生—心血管疾病]