乳腺癌分子亚型与MRI表现的相关性  

Correlation between molecular subtypes of breast cancer and MRI features

作　　者：徐晔[1] 张修石[1] 张红霞[1] 李鹏飞[1] 周洋[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院放射诊断科,黑龙江哈尔滨150000

出　　处：《中国介入影像与治疗学》2014年第8期497-501,共5页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的探讨不同分子亚型乳腺癌与MRI表现的相关性。方法回顾性分析121例经手术病理证实的乳腺癌患者,根据雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体(HER-2)表达状态,将乳腺癌分为HER-2过表达型、Luminal A型、Luminal B型和三阴性型,观察不同亚型乳腺癌MRI表现及其与分子亚型的相关性。结果 4种分子亚型乳腺癌T1WI多呈稍低信号[HER-2过表达型:68.00%(17/25),Luminal A型:66.67%(38/57),Luminal B型:76.19%(16/21),三阴性型55.56%(10/18)];HER-2过表达型多呈非肿块样强化[84.00%(21/25)],Luminal A型多呈不均匀强化[75.44%(43/57)],Luminal B型和三阴性型多呈环形强化[52.38%(11/21)、83.33%(15/18)];HER-2过表达型、Luminal B型和三阴性型时间-信号强度曲线多为廓清型[76.00%(19/25)、80.95%(17/21)和77.78%(14/18)],LuminalA型多为平台型[82.46%(47/57)];HER-2过表达型、Luminal B型和三阴性型多有伴随征象[80.00%(20/25)、76.19%(16/21)、66.67%(12/18)],Luminal A型49.12%(28/57)有伴随征象。乳腺癌增强MRI强化方式与分子亚型呈高度相关(C=0.737,P<0.001),时间-信号强度曲线类型与分子亚型呈中度相关(C=0.567,P<0.001)。结论乳腺癌分子亚型与MRI表现具有一定相关性,可通过MRI特征初步判断乳腺癌分子亚型。Objective To investigate the correlation between molecular subtypes of breast cancer and MRI features. Methods MRI data of 121 patients with breast cancer confirmed by pathology were retrospectively analyzed. According to the expression of estrogen receptor （ER）, progesterone receptor （PR） and human epidermal growth factor receptor-2 （HER-2）, the tumors were classified into HER-2 over-expressed subtype, Luminal A subtype, Luminal B subtype and tri- ple-negative subtype. MRI features of different molecular subtypes of breast cancer were observed, and the correlation be- tween molecular subtype and MRI features were analyzed. Results All the 4 molecular subtypes breast cancers mainly showed slightly hypo-intense signal on TlWI （HER-2 over-expressed： 68. 00% [-17/25], Luminal A： 66.67% [38/57], Luminal B： 76.19% [16/21], triple-negative： 55.56% [,10/18]）. On enhanced MRI, HER-2 over-expressed subtype mainly displayed non-mass-like enhancement （84.00% [-21/25]）, Luminal A subtype mainly displayed heterogeneous en- hancement （75.44% [43/57]）, Luminal B subtype and triple-negative subtype mainly displayed ring enhancement （52.38% [,,11/21] and 83.33% [15/18]）. The time-signal intensity curve mostly appeared as washout type in HER-2 o- ver-expressed subtype （76.00% [,19/25]）, Luminal B （80.95% [17/213） and triple-negative subtype （77.78% [14/183）, and platform type in Luminal A subtype （82.46% [47/57]）. Most of HER-2 over-expressed （80.00% [,20/25]）, Luminal B （76.19% [-16/21]）, triple-negative subtype （66.67% [12/18]） and 49.12% （28/57） of Luminal A subtype breast canc- ers had accompanied signs. The molecular subtype was highly correlated with enhancement features （C= 0. 737, P〈 0. 001） and moderately correlated with time-signal intensity curve type （C=0. 567, P〈0. 001）. Conclusion There is cor- relation between molecular subtype of breast cancer and MRI features. Molecular subtype of breast cancer can be initially predicted through MRI fe

关 键 词：乳腺肿瘤 磁共振成像 分子亚型 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.9[医药卫生—诊断学]