六郁汤对行为绝望模型小鼠的抗抑郁作用  

Antidepressant-like effects of Liu-yu decoction in mice

作　　者：朴颖[1] 杨帆[2] 周金田 宋旭东[1] 于海玲[2] 

机构地区：[1]延边大学 [2]延边大学医学院,吉林延吉133002

出　　处：《延边大学医学学报》2014年第2期105-107,共3页Journal of Medical Science Yanbian University

基　　金：延边大学科技发展计划;项目号:2013300-602013106

摘　　要：[目的]探讨古方六郁汤对行为绝望模型小鼠的抗抑郁作用.[方法]灌胃给予六郁汤大、中、小剂量组小鼠10.0,5.0,2.5g/kg六郁汤,连续给药7d,第7d给药后60min进行强迫游泳实验,测定不动时间;悬尾实验分组和给药方法同上;旷场实验中灌胃给予六郁汤组小鼠10.0g/kg六郁汤,连续给药7d,第7d给药后60min进行旷场实验,记录水平活动、垂直活动及修饰次数.[结果]在强迫游泳实验中,与模型对照组相比较,六郁汤大、中、小剂量组及阳性对照组不动时间明显缩短(P<0.05,P<0.01);在悬尾实验中,与模型对照组相比较,六郁汤大、中、小剂量组及阳性对照组不动时间明显缩短(P<0.05,P<0.01);在旷场实验中,与正常对照组相比较,六郁汤组及阳性对照组水平活动、垂直活动及修饰次数均无明显改变(P>0.05).[结论]六郁汤对行为绝望模型小鼠有抗抑郁作用,无中枢兴奋作用.OBJECTIVE To investigate the antidepressant-like effects of Liu-Yu decoction（LYD）.METHODSThe antidepressant-like effects was investigated in mice using the tail suspension test（TST）,the forced swimming test（FST）and open-field test（OFT）.The high,middle,and low dose group of LYD was treated with LYD（2.5,5.0,and 10.0g/kg,po）,for 7consecutive days once daily.One hour after the last administration,the mice were submitted to the FST.In TST,grouping and administration methods was as above.In OFT,the 10.0g/kg of LYD was treated for 7consecutive days once daily.One hour after the last administration,the mice were submitted to the OFT,and the locomotion,rearing,and grooming of the spontaneous locomotor activities were recorded.RESULTS As compared with the model group,the immobility significantly decreased in the high,middle,and low dose group of LYD（P〈0.05,P〈0.01）.Moreover,the high dose group of LYD did not significantly change motor activity in a spontaneous behavioral test（P〉0.05）.CONCLUSIONLYD administered orally reduced immobility in TST and FST,and had no effect on spontaneous activity in mice,so may be have some antidepressant-like effects.

关 键 词：抑郁症 六郁汤 小鼠 

分 类 号：R285.5[医药卫生—中药学]