快速上浮脱险致减压病动物肺组织病理改变的研究  

Pathological changes in lung tissue during fast floating escape-induced decompression sickness

作　　者：攸璞[1] 方以群[1] 王海涛[1] 包晓辰[1] 张师[1] 马骏[1] 王芳芳[1] 

机构地区：[1]海军医学研究所潜水医学研究室,上海200433

出　　处：《军事医学》2014年第7期490-492,共3页Military Medical Sciences

基　　金：总后勤部资助项目(12A106);海军后勤部资助项目(11A101)

摘　　要：目的研究快速上浮脱险致减压病动物肺组织病理的改变特点。方法雄性SD大鼠80只,随机选取60只为模拟快速上浮脱险组(简称脱险组),其余20只为空白对照组。空白对照组仅放于加压舱内相同时间不做加压处理。脱险组空气加压以2t/7指数速率加压至1.5 MPa,停留4 min后匀速减压至常压出舱。出舱后0.5 h观察大鼠存活率,留取所有大鼠肺组织作病理检查,对肺组织损伤程度进行评分,利用R语言进行统计分析。结果大鼠死亡率50%,肺组织病理主要以肺间质增厚、水肿、充血为主要特点。Kruskal非参检验分析发现各组间总体上有显著差异(P=0.0016),用Nemenyi检验作两两比较发现,脱险组死亡与未死亡动物的评分与空白对照组相比均有显著性差异(P<0.05),而死亡与未死亡动物之间无显著性差异。结论快速上浮脱险所致减压病可显著破坏血肺屏障引起肺组织水肿。Objective To study the pathological changes of lung tissues during fast floating escape-induced decompression sickness.Methods Eighty male SD rats were randomly divided into 2 groups,60 in fast floating escape group（escape group）,and 20 in control group.Rats in the control group were only put in a cabin under the same atmospheric pressure（ATM）.Rats in escape group were pressurized to 1.5 MPa by pressure air at the 2^t/7exponential rate and stayed for 4 min till decompression.Then the rats＇ survival rate was observed after 0.5 h,lung tissue specimens were collected from each rat,the pathological score was taken,according to the degree of lung injury and the R language was used for statistical analysis.Results The mortality rate was 50%.Lung tissues of these rats were pathologically characterized by stromal lung thickening,edema,and hyperemia.Kruskal non-parametric test analysis found a significant difference（P = 0.0016）between the two groups.Nemenyi test was used in pairwise comparison.The death and survival animals in escape group compared with the control group,the scores were significantly different（P〈0.05）.The scores had no significant difference between the deach and survival animal in escape group.Conclusion Decompression sickness caused by fast floating escape can significantly damage the blood-lung barrier to cause pulmonary edema.

关 键 词：快速上浮脱险 减压病 病理评分 

分 类 号：R845.2[医药卫生—航空、航天与航海医学]