自然杀伤细胞的抗体依赖性细胞毒效应在丙型肝炎病毒感染中的作用  

Antibody-dependent cellular cytotoxicity by natural killer cells in HCV infection

作　　者：沈弢[1] 庄辉[1] 

机构地区：[1]北京大学医学部基础医学院病原生物学系和感染病中心,北京100191

出　　处：《中国病毒病杂志》2014年第3期161-165,共5页Chinese Journal of Viral Diseases

基　　金：国家"十二五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2012ZX10002003);国家自然科学基金面上项目(81271826)

摘　　要：自2005年丙型肝炎病毒（HCV）病毒体外培养[1]获得成功至今,HCV感染相关研究取得较大进展。大量研究显示,HCV感染所致的免疫损伤是引起肝内炎症的主要原因。一直以来,对HCV病毒性肝炎免疫应答的研究主要集中在适应性免疫应答,而固有免疫介导的抗HCV作用机制仍不清楚。人体肝脏内含有大量的固有免疫细胞,如NK细胞、NK T细胞、γδT细胞等,此类细胞约占整个肝脏淋巴细胞的2/3。Hepatitis C virus （HCV） infection still remains a severe public health issue globally. Recent research progress has highlighted that the immune status of natural killer （NK） cells is one of the key factors influencing the outcome of acute HCV infected patients, progressing to either spontaneous resolvers or chronic infection. NK cells not only perform direct cytotoxicity on infected cells via the cellular surface activating/inhibitory receptors, but also mediate antibody-dependent cell-mediated cytotoxicity （ADCC） by surface CD16 molecules. The role of NK cell-mediated ADCC （NK-ADCC） in HCV infection is still unraveled. With the improvement and simplification of the novel flow cytometry techniques for ADCC assay, NK-ADCC effect in HCV infection would be easily available to be evaluated in the near future. The NK-ADCC based intervention strategies may contribute to the immune control of HCV infection.

关 键 词：丙型肝炎病毒 抗体依赖性细胞介导的细胞毒效应 自然杀伤细胞 自发清除 TOLL样受体 

分 类 号：R392[医药卫生—免疫学]