通过血液透析途径感染的丙型肝炎患者丙型肝炎病毒基因型若干问题  

Hepatitis C virus infection in hemodialysis patients:genotypes,epidemiology and treatment

作　　者：杨景毅[1] 叶晓玲[2] 程书权[1] 

机构地区：[1]桂林医学院第三附属医院(桂林市第三人民医院),广西桂林541002 [2]桂林医学院研究生院,广西桂林541004

出　　处：《中国病毒病杂志》2014年第3期235-239,共5页Chinese Journal of Viral Diseases

摘　　要：迄今,丙型肝炎病毒（hepatitis C virus,HCV）感染仍是一个重要的全球性公共卫生问题。由于HCV进入人体后起病隐匿,早期常无明显的肝功能受损表现,在体内不易被免疫系统清除,慢性化概率较高,也是肝硬化、原发性肝癌（HCC）等疾病的主要祸首之一[1]。由于HCV传染性强且缺乏有效的疫苗,Patients under hematodialytic procedures are at high risk of hepatitis C virus （HCV） infec tion. HCV genotypes from this patient population are related to that from other populations but there are some differences. Transfusion, frequent change of clinics for hematodialysis, lack of fully disinfection to the equipment and substandard operation procedure are the main risk factors to HCV infection. Interferon in combination with ribavirin can reach a higher continuous virological response rate, but it would also bring more side effects. In this review, we discuss the epidemiologic distribution of different HCV genotype in hematodialysis patients, the route of HCV transmission and the treatment.

关 键 词：丙型肝炎病毒 血液透析 基因类型 

分 类 号：R512.63[医药卫生—内科学]