Antibacterial Properties of Ti-6Al-4V-xCu Alloys  

作　　者：Ling Ren Zheng Ma Mei Li Yu Zhang Weiqiang Liu Zhenhua Liao Ke Yang 

机构地区：[1]Institute of Metal Research,Chinese Academy of Sciences [2]Department of Orthopedic Surgery,Guangzhou General Hospital of Guangzhou Military Command [3]Research Institute of Tsinghua University in Shenzhen,Shenzhen High-Tech Industrial Estate

出　　处：《Journal of Materials Science & Technology》2014年第7期699-705,共7页材料科学技术（英文版）

基　　金：financially supported by the National Basic Research Program of China(No.2012CB619101);the National Natural Science Foundation of China(No.81271957);the Basic Research Project of Shenzhen,China(No. JCYJ20120616142847342)

摘　　要：Surgical implant-associated bacterial infection is becoming a serious clinical problem. A series of copper-bearing titanium alloy, Ti-6Al-4V-xCu （x = 1, 3, 5 wt%）, were fabricated in the present study in order to reduce the hazard of the bacterial infection problem by means of the strong antibacterial ability of Cu element. The metallography, X-ray diffraction, antibacterial ability, corrosion resistance and cytotoxicity of Ti-6Al-4V-xCu alloys were preliminarily studied with comparison to the commercial medical Ti-6Al-4V alloy. The Ti-6Al- 4V-xCu alloys showed obvious antibacterial abilities with good corrosion resistance and cytocompatibility, and the antibacterial role was enhanced with increasing Cu content, which has significant potential for clinical applications as surgical implant materials.Surgical implant-associated bacterial infection is becoming a serious clinical problem. A series of copper-bearing titanium alloy, Ti-6Al-4V-xCu （x = 1, 3, 5 wt%）, were fabricated in the present study in order to reduce the hazard of the bacterial infection problem by means of the strong antibacterial ability of Cu element. The metallography, X-ray diffraction, antibacterial ability, corrosion resistance and cytotoxicity of Ti-6Al-4V-xCu alloys were preliminarily studied with comparison to the commercial medical Ti-6Al-4V alloy. The Ti-6Al- 4V-xCu alloys showed obvious antibacterial abilities with good corrosion resistance and cytocompatibility, and the antibacterial role was enhanced with increasing Cu content, which has significant potential for clinical applications as surgical implant materials.

关 键 词：TI-6AL-4V Cu-bearing titanium alloy Antibacterial property 

分 类 号：TG146.23[一般工业技术—材料科学与工程] R318.08[金属学及工艺—金属材料]