口服阿卡波糖治疗80例2型糖尿病患者的临床效果分析  

Clinical effect analysis of oral acarbose in the treatment of 80 patients with T2DM

作　　者：雷芳 刘秋均[2] 

机构地区：[1]重庆益民医院内科,重庆荣昌402463 [2]泸州医学院基础医学院生物化学教研室,四川泸州646000

出　　处：《现代医药卫生》2014年第16期2436-2437,共2页Journal of Modern Medicine & Health

摘　　要：目的探讨口服葡萄糖苷酶抑制剂阿卡波糖治疗2型糖尿病的临床效果,为2型糖尿病患者的用药治疗提供依据。方法选取2011年7月至2013年7月在该院住院的2型糖尿病患者80例,首次给予口服阿卡波糖75～150mg,以后根据血糖水平进行个体化调整剂量,口服治疗3个月后,观察患者空腹、餐后2小时血糖及糖化血红蛋白的变化,以及治疗前后的血脂、体质量变化,并观察患者的不良反应。结果治疗3个月后,80例患者空腹、餐后2小时血糖以及糖化血红蛋白明显下降,治疗后的血脂明显优于治疗前,差异均有统计学意义（P〈0.05）,而治疗前后患者体质量并未发生明显变化,差异无统计学意义（P〉0.05）。3例患者出现腹胀、4例患者出现腹泻等不良反应,经对症治疗后逐渐好转。结论口服阿卡波糖能够明显控制患者的血糖水平,并能够长期维持,不良反应较少,值得在临床上广泛使用。Objective To explore the clinical efficacy of acarbose-glycosidase inhibitor for type 2 diabetes mellitus（T2DM）,in order to provide the basis for drug treatment of T2 DM patients. Methods A total of 80 patients with T2 DM,who hospitalized from June 2011 to June 2013,were administered with 75-150 mg acarbose orally for the first time,then the dosage was adjusted individually according to the blood glucose level. 3 months after oral medication,the changes of fast plasma glucose（FPG）,2hPG,glycosylated hemoglobin,and the changes of serum lipid and body mass before and after treatment were observed,as well as the adverse reactions. Results Three months after treatment,the levels of FPG,2hPG and glycosylated hemoglobin of all the 80 cases decreased obviously,and the serum lipid after treatment was better than that before treatment with statistically significant difference（P〈0.05）;the body mass had no obvious change before and after treatment,and the difference had no statis tical significance（P〉0.05）. Abdominal distention appeared in 3 cases,diarrhea and other adverse reactions occurred in 4 cases,which all were getting better gradually after symptomatic treatment. Conclusion Oral acarbose can obviously control the patient′s blood sugar level with long-term maintenance and less adverse reactions,so it is worthy of application widely in clinic.

关 键 词：糖尿病 2型 药物疗法 阿卡波糖 治疗结果 

分 类 号：R587.1[医药卫生—内分泌]