重症监护病房患者耐甲氧西林金黄色葡萄球菌感染及耐药性研究  

RESEARCH ON METHICILLIN RESISTANT Staphylococcus aureus INFECTIONS AND DRUG RESISTANCE OF THE ICU PATIENTS

作　　者：赵德军[1] 胡昭宇[1] 曹雁[1] 武静[1] 杨通钰[1] 

机构地区：[1]解放军第44医院,贵州贵阳550009

出　　处：《中国消毒学杂志》2014年第8期835-837,840,共4页Chinese Journal of Disinfection

摘　　要：目的了解重症监护病房住院患者耐甲氧西林金黄色葡萄球菌的感染情况及其耐药性。方法通过回顾性调查方法,对某医院重症监护病房2010年1月-2011年12月住院患者送检标本进行检测,分析耐甲氧西林金黄色葡萄球菌感染与耐药性情况。结果两年时间内该重症监护病房共送检患者标本1 415份,分离出病原菌1 102株,其中金黄色葡萄球菌133株,含耐甲氧西林金黄色葡萄球菌112株,构成比为84.2%。以下呼吸道感染耐甲氧西林金黄色葡萄球菌最多,构成比为66.2%。耐甲氧西林金黄色葡萄球菌对临床常用抗菌药物耐药较为普遍,其对万古霉素、替考拉宁、替加环素及利奈唑胺均敏感。结论该医院重症监护病房患者耐甲氧西林金黄色葡萄球菌感染率较高,对抗菌药物呈多重耐药性,加强耐药菌监测和严格执行消毒隔离制度是有效的防控措施。Objective To understand methicillin- resistant Staphylococcus aureus（ MRSA） infections and drug resistance of the Intensive Care Unit（ ICU） inpatients. Methods The retrospective survey was used to detect ICU patient samples from a hospital ICU in year 2010 January - 2011 December and to analyze status of MRSA infection and drug resistance. Results There were1415 samples from the ICU patients tested in two years and 1102 strains of bacteria were isolated,including 133 strains of Staphylococcus aureus. There were 112 strains of MRSA and the ratio was 84. 2%. The MRSA detected from lower respiratory tract infections was the most and the ratio was 66. 2%. The drug resistance of MRSA to commonly used antimicrobial drug was common,which were sensitive to Vancomycin,Teicoplanin,Tigecycline and Linezolid. Conclusion The MRSA infection rate of hospital ICU patients is higher and it shows multi- drug resistance to commonly used drug. So strengthening the monitoring of drug resistance bacteria and strict implementation of disinfection and isolation system are effective prevention and control measures.

关 键 词：重症监护病房 耐甲氧西林金黄色葡萄球菌 医院感染 抗菌药物 耐药性 

分 类 号：R378[医药卫生—病原生物学]