Ⅶ因子激活蛋白酶(FSAP)的研究进展  

Research progress of factor Ⅶ-activating protease(FSAP)

作　　者：薛明明[1] 宋振举[1] 徐云洁[1] 栾骁[1] 陈斌[1] 樊帆[1] 陈东旭[1] 姚晨玲[1] 童朝阳[1] 陶振钢[1] 

机构地区：[1]复旦大学附属中山医院急诊科,上海200032

出　　处：《复旦学报（医学版）》2014年第4期556-559,564,共5页Fudan University Journal of Medical Sciences

基　　金：复旦大学附属中山医院青年科研基金(2013ZSQN038)~~

摘　　要：Ⅶ因子激活蛋白酶(factorⅦ-activating protease,FSAP)是近年发现的一种存在于外周循环血浆中的丝氨酸蛋白酶。初始FSAP是无活性的酶原,它可由阴离子聚合物如肝素、右旋糖酐硫酸盐、钙离子等细胞内成分激活,也可由细胞外RNA、组蛋白激活,单链无活性的酶原变为双链有活性的酶。FSAP的生物学功能也可被多种物质抑制,如TFPI、C1-抑制剂、α2抗纤维蛋白溶酶等。FSAP基因含有13个外显子,长35 kb,位于染色体10q25-q26,两个主要的单核苷酸多态性位点是G534E(MⅠ)和E393Q(MⅡ)。前者为当前研究热点,与血管栓塞性疾病密切相关。Factor Ⅶ-activating protease （FSAP） is a newly found serine protease existing in peripheral circulating blood plasma.Initially,FSAP is a single-chain zymogen.The conversion of the single chain FSAP zymogen into the active two chain enzyme involves intracellular substances including anionic polymers （for example heparin）,dextran sulfate,calcium ion,or extracellular substances including RNA or histone.The biological function of FSAP can be suppressed by many materials such as TFPI,serine kinase antagonist C1,antifibrinolysin 2α,etc.FSAP contains 13 exons which is 35 kb in length and located at chromosome 10q25-q26.However,the main parts of FSAP gene are two singlenucleotide polymorphisms G534E （M Ⅰ） and E393Q （MⅡ）.The former is currently a hot topic in this area,and closely related to vascular occlusive diseases.

关 键 词：Ⅶ因子激活蛋白酶(FSAP) 激活 抑制 血管栓塞性疾病 

分 类 号：Q556.3[生物学—生物化学]