依达拉奉对成人体外循环心脏手术中脑损伤的保护作用  

Role of edaravone in protection of cerebral injury in patients with cardiopulmonary bypass

作　　者：胡强[1] 高国栋[1] 于坤[1] 龙村[1] 

机构地区：[1]中国医学科学院,北京协和医学院,国家心血管病中心,阜外心血管病医院,心血管疾病国家重点实验室,北京100037

出　　处：《实用临床医药杂志》2014年第11期14-16,25,共4页Journal of Clinical Medicine in Practice

摘　　要：目的探讨依达拉奉对成人体外循环心脏手术中脑损伤的保护作用。方法将80例体外循环下行心脏手术患者分成依达拉奉组(Y组)和对照组(C组),每组40例。应用酶联免疫法(ELISA)检测CPB开始时(T1)、CPB停止时(T2)、CPB后6 h(T3)、CPB后12 h(T4)、CPB后24 h(T5)的NSE及S-100β蛋白含量。结果 2组患者CPB时间、主动脉阻断时间、ICU监护时间在各个时间点差异均无统计学意义(P>0.05);Y组麻醉初醒时间和术后呼吸机辅助通气时间均显著短于对照组(P<0.01)。CPB停机时、6 h、12 h,C组S-100β和NSE水平明显高于Y组(P<0.01)。CPB后24 h时,C组S-100水平明显高于Y组(P<0.01),NSE2组无显著差异(P>0.05)。CPB停机时、6、12和24 h,2组S-100β和NSE水平均明显高于CPB开始时(P<0.01)。结论在体外循环心脏手术中,依达拉奉可以有效清除脑缺血再灌注损伤产生的自由基。Objective To explore the role of edaravone in protection of cerebral injury in patients with cardiopulmonary bypass（CPB）.Methods 80 patients were divided into edaravone group（group Y,n =40） and control group（group C,n =40）.Concentrations of S-100β and NSE were measured by using ELASA at time points of the beginning of CPB （T1）,the end of CPB （T2）,6 hours after CPB（T3）,12 hours after CPB（T4）,24 hours after CPB （T5）.Results The time of mechanical ventilation and anesthesia recovery in group C were significant longer than group Y（P＜ 0.01）.The concentrations of NSE and S-100β in group C were significant higher than group Y at the time point of T2,T3,T4（P＜0.01）.In T5,the concentration of S-100β in group C was significant higher than group Y（P ＜ 0.01）.The concentrations of NSE and S-100β in T2,T3,T4,T5 were significant higher than T1 in both groups（P ＜ 0.01）.Conclusion Edaravone plays a protective role in cerebral injury by radicals scavenging during CPB.

关 键 词：体外循环 依达拉奉 脑保护 神经元特异性烯醇化酶 

分 类 号：R651.1[医药卫生—外科学]