血浆纤溶酶原激活物抑制物-1在稳定性心绞痛及不稳定性心绞痛中的鉴别价值  

Value of plasminogen activator inhibitor-1 in differential diagnosis of stable angina and unstable angina

作　　者：武华越[1] 

机构地区：[1]湖北省枣阳市第一人民医院,湖北枣阳441200

出　　处：《实用临床医药杂志》2014年第13期16-19,共4页Journal of Clinical Medicine in Practice

摘　　要：目的探索血浆纤溶系统是否有助于鉴别不稳定性心绞痛及稳定性心绞痛。方法回顾性分析2010年1月至2014年1月在我院接受治疗的冠心病(心绞痛)患者的临床资料。依据患者冠心病类型分为2组:观察组:不稳定性心绞痛;对照组:稳定性心绞痛。结果共纳入患者178例,观察组87(48.88%)例,对照组91(51.12%)例。观察组患者血浆CRP水平显著高于对照组(11.83±4.92 vs 7.03±3.05;t=7.861,P<0.001);观察组血浆纤溶酶原激活物抑制物-1(PAI-1)水平显著高于对照组(43.86±10.97 vs37.97±7.89;t=4.126,P<0.001)。心绞痛患者血浆CRP与PAI-1呈现显著正相关(r=0.189,P=0.012)。PAI-1区分稳定性心绞痛及不稳定性心绞痛的诊断分界点为109.5 mg/L,曲线下面积为0.947,敏感性为90.91%,特异性为91.11%。结论 PAI-1在不稳定性心绞痛患者外周血中显著升高,其区分稳定性心绞痛与不稳定性心绞痛的价值优于CRP。Objective To explore the value of plasminogen activator inhibitor-1 （PAI-1）in differential diagnosis of stable angina and unstable angina.Methods Clinical materials of 178 pa-tients with angina were analyzed retrospectively,and they were divided into Observation group （unsta-ble angina,n =87）and control group （stable angina,n =91）according to type of angina.Results Levels of CRP and PAI-1 in the observation group were significantly lower than those in the control group （P 〈0.001）.There was a significant positive correlation between CRP and PAI-1 （r =0.189, P =0.012）in patients with angina.ROC analysis showed PAI-1 was able to differentiate unstable an-gina and stable angina with a cut-off value of 109.5 mg/L,a AUC of 0.947,a sensibility of 90.91%and a specificity of 91.11%.Conclusion Unstable angina patients have a higher level of PAI-1 than stable angina patients.PAI-1 can be used to differentiate unstable angina and stable angina.

关 键 词：心绞痛 纤溶系统 鉴别诊断 心血管疾病 

分 类 号：R541[医药卫生—心血管疾病]