男性初发2型糖尿病患者血游离脂肪酸、尿酸、睾酮与C肽间的相关性  

Relevance exploration of blood free fatty acid,uric acid and Testosterone with C peptide in male patients with incipient type 2 diabetes mellitus

作　　者：朱榕峰[1] 陈素红[1] 辜斌[1] 黄胜立[1] 

机构地区：[1]南京军区福州总医院九五临床部内科,福建莆田351100

出　　处：《实用临床医药杂志》2014年第15期8-10,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金项目(11321572);福建省莆田市科技计划项目(2011S12(1))

摘　　要：目的进行男性初发2型糖尿病患者血游离脂肪酸、尿酸、睾酮与C肽的相关性分析。方法选取本院门诊及住院的初发2型糖尿病患者41例,检测相关指标与C肽进行的相关性分析。结果血清C肽与年龄、BMI、血尿酸水平、空腹胰岛素、游离脂肪酸、胰岛素抵抗(HOMA-IR)、胰岛素分泌指数(HOMA-B)呈显著正相关,与糖化血红蛋白呈负相关,与睾酮无显著相关性,且多元线性回归分析显示尿酸是C肽的独立影响因素。结论男性初发2型糖尿病患者年龄、肥胖、尿酸、游离脂肪酸、糖化血红蛋白与C肽密切相关,高尿酸血症是C肽的独立影响因素,而睾酮未示与C肽的相关性。Objective To conduct a relevance analysis of blood free fatty acid（ FFA）,uric acid（ UA） and testosterone（ TTE） with C peptide in male patients with incipient type 2 diabetes mellitus（ T2DM）. Methods A total of 41 patients with incipient T2 DM in outpatient or hospitalized in our hospital were selected to detect the relevance between relevant indexes and C peptide. Results Serum C peptide was in positive relation with ages,body mass index（ BMI）,UA level,fasting insulin,FFA,homeostasis model assessment of Insulin Resistance（ HOMA-IR） and homeostasis model assessment-B（ HOMA-B） and in reverse connection with glycated hemoglobin,but in no relationship with TTE. Additionally,the multiple linear regression analysis showed that UA was an independent risk factor for C peptide. Conclusion Serum C peptide is in close association with ages,obesity,UA,FFA and glycated hemoglobin and its independent risk factor is Hyperuricemia,which has no correlation with TTE in male patients with incipient T2 DM.

关 键 词：男性初发2型糖尿病 游离脂肪酸 尿酸 睾酮 相关性 

分 类 号：R587.1[医药卫生—内分泌]