血小板参数在成人重度原发免疫性血小板减少症诊断和疗效判断中的意义  

Significance of platelet parameters in the diagnosis and efficacy-evaluation of adult patients with severe primary mmune thrombocytopenia

作　　者：季美华[1] 陶健[1] 陈进[1] 黄泉[1] 马海佳[1] 

机构地区：[1]南通大学第二附属医院血液科,江苏南通226001

出　　处：《实用临床医药杂志》2014年第15期140-142,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金项目(11321267);2013年南通市指导性课题(HS13950)

摘　　要：目的探讨血小板参数的检测在成人重度原发免疫性血小板减少症(ITP)诊断和疗效判断的临床意义。方法选取本院收治的34例原发重度ITP患者为观察组,另选取30例本院同期健康体检者为对照组。记录2组治疗前和观察组治疗3、7 d后血小板参数值。结果治疗前,观察组血小板计数(PLT)、血小板比积(PCT)显著低于对照组(P<0.05),平均血小板体积(MPV)明显高于对照组(P<0.05),而血小板分布宽度(PDW)无明显差异(P>0.05)。与治疗前比较,观察组治疗3 d后PLT、PCT、MPV均明显增加(P<0.05),治疗7 d后PLT、PCT、PDW均有显著增加(P<0.05)。结论血小板参数对判断重度原发ITP患者病情进展和疗效均有重要临床意义。Objective To explore the clinical significance of detecting platelet parameters in the diagnosis and efficacy- evaluation of adult severe primary immune thrombocytopenia（ ITP）.Methods Thirty- four adult patients with primary ITP admitted in our hospital served as observation group while another 30 healthy people undergoing physical examination as control group. Platelet parameters on both groups before treatment and in observation group 3and 7 days after treatment were observed. Results Before treatment,observation group was evidently lower in platelet count（ PLT） and plateletocrit（ PCT） and obviously higher in mean platelet volume（ MPV） than control group（ P〈 0. 05）,but there was no significant difference in platelet distributive width（ PDW）（ P〉0. 05）.Compared with treatment before,PLT,PCT,MPV increased more markedly 3 d after treatment while PLT,PCT,PDW increased significantly 7 days after treatment in observation group（ P〈 0. 05）. Conclusion Platelet parameters have important clinical significance in evaluating the progression and efficacy of adult patients with severe primary ITP.

关 键 词：原发免疫性血小板减少症 血小板参数 临床意义 

分 类 号：R558[医药卫生—血液循环系统疾病]